Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Abstract Arginine shows Jekyll and Hyde behavior in several respects. It participates in
protein folding via ionic and H-bonds and cation-pi interactions; the charge and …

Recent advances in chemical proteomics have begun to characterize the reactivity and
ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic …

Natural products perennially serve as prolific sources of drug leads and chemical probes,
fueling the development of numerous therapeutics. Despite their scarcity, natural products …

RNA–protein interaction networks govern many biological processes but are difficult to
examine comprehensively. We devised ribonucleoprotein networks analyzed by mutational …

Intrahepatic cholangiocarcinoma (ICC) contains abundant myofibroblasts derived from
hepatic stellate cells (HSCs) through an activation process mediated by TGF-β. To …

The HIV-1 virion structural polyprotein, Gag, is directed to particle assembly sites at the
plasma membrane by its N-terminal matrix (MA) domain. MA also binds to host tRNAs. To …

Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native
or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition …

RNA recognition by proteins is central to biology. Here we demonstrate the existence of a
recurrent structural motif, the “arginine fork”, that codifies arginine readout of cognate …

Recent efforts to identify RNA binding proteins in various organisms and cellular contexts
have yielded a large collection of proteins that are capable of RNA binding in the absence of …