Disorders in the regulatory arm of the adaptive immune system result in autoimmune‐
mediated diseases. While systemic immunosuppression is the prevailing approach to …

The immune system is traditionally classified as a defense system that can discriminate
between self and non-self or dangerous and non-dangerous situations, unleashing a …

The hair follicle is a dynamic mini-organ that has specialized cycles and architectures with
diverse cell types to form hairs. Previous studies for several decades have investigated …

Inflammatory skin diseases highlight inflammation as a central driver of skin pathologies,
involving a multiplicity of mediators and cell types, including immune and non-immune cells …

Regulatory T cells (Tregs), a suppressive subpopulation of T cells, are potent mediators of
peripheral tolerance, responsible for immune homeostasis. Many autoimmune diseases …

Stem cells heal wounds. In this issue of Immunity, Luan et al. demonstrate that epidermal
stem cells orchestrate the recruitment of regulatory T (Treg) cells and neutrophils during …

Abstract Interleukin-2 (IL-2) holds promise for the treatment of cancer and autoimmune
diseases, but its high-dose usage is associated with systemic immunotoxicity. Differential IL …

Recombinant human IL‐2 has been used to treat inflammatory diseases and cancer;
however, side effects like skin rashes limit the use of this therapeutic. To identify key …

Hair is a biofilament with unique multi-dimensional values. In human, in addition to
physiologic impacts, hair loss and hair related disorders can affect characteristic features …

Fibroblasts coordinate the response to tissue injury, directing organ regeneration versus
scarring. In the central nervous system (CNS), fibroblasts are uncommon cells enriched at …