Oxadiazole: A highly versatile scaffold in drug discovery
N Desai, J Monapara, A Jethawa… - Archiv der …, 2022 - Wiley Online Library
As a pharmacologically important heterocycle, oxadiazole paved the way to combat the
problem associated with the confluence of many commercially available drugs with different …
problem associated with the confluence of many commercially available drugs with different …
New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in …
A new series of benzoxazole derivatives were designed and synthesised to have the main
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic activities were …
Recent advances in nitrogen-containing heterocyclic compounds as receptor tyrosine kinase inhibitors for the treatment of cancer: Biological activity and structural …
Erratic cell proliferation is the initial symptom of cancer, which can eventually metastasize to
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
other organs. Before cancer becomes metastatic, its spread is triggered by pro-angiogenic …
(E)-N-(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth …
(E)-N-(3-(1-(2-(4-(2, 2, 2-Trifluoroacetamido) benzoyl) hydrazono) ethyl) phenyl)
nicotinamide (compound 10) was designed as an antiangiogenic VEGFR-2 inhibitor with the …
nicotinamide (compound 10) was designed as an antiangiogenic VEGFR-2 inhibitor with the …
The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Corresponding to the reported features of anti-VEGFR-2-approved compounds, a new 1 H-
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo …
MM Khalifa, AA Al-Karmalawy, EB Elkaeed… - Journal of Enzyme …, 2022 - Taylor & Francis
This research presents the design and synthesis of a novel series of phthalazine derivatives
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In vitro testing of the new …
In silico, in vitro VEGFR-2 inhibition, and anticancer activity of a 3-(hydrazonomethyl)naphthalene-2-ol derivative
In agreement with the general features of VEGFR-2 inhibitors, a new naphthalene analog
(compound 7) has been designed and synthesized. The inhibitory potential of compound 7 …
(compound 7) has been designed and synthesized. The inhibitory potential of compound 7 …
Discovery of new VEGFR-2 inhibitors: design, synthesis, anti-proliferative evaluation, docking, and MD simulation studies
EB Elkaeed, RG Yousef, MM Khalifa, A Ibrahim… - Molecules, 2022 - mdpi.com
Four new nicotinamide-based derivatives were designed as antiangiogenic VEGFR-2
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
inhibitors. The congeners were synthesized possessing the pharmacophoric essential …
Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors …
AM Saleh, HA Mahdy, MA El-Zahabi, ABM Mehany… - RSC …, 2023 - pubs.rsc.org
A novel series of pyrimidine-5-carbonitrile derivatives bearing benzylidene and hydrazone
moieties with different linkers (spacers) were designed and synthesized as possible …
moieties with different linkers (spacers) were designed and synthesized as possible …
Design, molecular docking, synthesis, anticancer and anti-hyperglycemic assessments of thiazolidine-2, 4-diones bearing sulfonylthiourea moieties as potent VEGFR …
Newly designed thiazolidine-2, 4-diones 3–7a–c were synthesized, and their anticancer
activities were screened against three cancer lines. They showed potent activities against …
activities were screened against three cancer lines. They showed potent activities against …