Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its
frequency and severity, prevention of pertussis has been considered an important public …

Pertussis toxin and adenylate cyclase toxin are two important virulence factors of Bordetella
pertussis, the bacterial cause of the respiratory disease pertussis or whooping cough. In …

Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains
one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell …

Combination vaccines containing a monocomponent acellular pertussis (aP) vaccine,
manufactured at Statens Serum Institut (SSI), Denmark, have successfully controlled …

Despite widespread vaccination, pertussis rates are rising in industrialized countries and
remain high worldwide. With no specific therapeutics to treat disease, pertussis continues to …

En los últimos años se está observando una reemergencia de la tos ferina en los países con
amplias coberturas vacunales, con la aparición de brotes importantes. Este aumento de la …

To overcome the limitations of the current pertussis vaccines, those of limited duration of
action and failure to induce direct killing of Bordetella pertussis, a synthetic scheme was …

Acellular multivalent vaccines for pertussis (DTaP and Tdap) prevent symptomatic disease
and infant mortality, but immunity to Bordetella pertussis infection wanes significantly over …

Pertussis toxin (PT) is one of the major virulence factors of Bordetella pertussis and the
primary component of all pertussis vaccines available to date. Because of its various …

Background: Hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-
hepatitis B-Haemophilus influenzae type b (DTaP-IPV-HB-PRP-T)–containing vaccines are …