Covering: up to February 2014 The methylerythritol 4-phosphate (MEP) pathway is the
recently discovered source of isoprenoid precursors isopentenyl diphosphate (IDP) and …

Enzymes that use thiamin diphosphate (ThDP), the biologically active derivative of vitamin
B1, as a cofactor play important roles in cellular metabolism in all domains of life. The …

The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the biosynthesis of
isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the precursors for …

Isoprenoids are a very large and diverse family of metabolites required by all living
organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate …

Target-directed dynamic combinatorial chemistry (tdDCC) enables identification, as well as
optimization of ligands for un (der) explored targets such as the anti-infective target 1-deoxy …

The bacterial metabolic enzyme 1-deoxy-d-xylulose-5-phosphate synthase (DXPS)
catalyzes the thiamin diphosphate (ThDP)-dependent formation of DXP from pyruvate and d …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a severe infectious
disease in need of new chemotherapies especially for drug-resistant cases. To meet the …

1-Deoxy-d-xylulose-5-phosphate synthase (DXS) and 1-deoxy-d-xylulose-5-phosphate
reductoisomerase (DXR) genes are the key enzyme genes of terpenoid biosynthesis but still …

Increasing demands for bioactive compounds have motivated researchers to employ micro‐
organisms to produce complex natural products. Currently, Bacillus subtilis has been …

New antimicrobial strategies are needed to address pathogen resistance to currently used
antibiotics. Bacterial central metabolism is a promising target space for the development of …