B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Our pathophysiological concept of the most common central nervous system demyelinating
disease, multiple sclerosis, strikingly evolved by recent discoveries suggesting that B …

B cells are important in the pathogenesis of multiple sclerosis (MS) and some of the effects
are not dependent on maturation of B cells into immunoglobulin (Ig) producing plasmablasts …

The diagnosis of multiple sclerosis is based on dissemination in time and space. Before
2010 lack of evidence for dissemination in space could be substituted by a paraclinical test …

Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …

Flow cytometry facilitates the detection of a large spectrum of cellular characteristics on a per
cell basis, determination of absolute cell numbers and detection of rare events with high …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Once thought to be primarily driven by T cells, B cells are emerging as central …

Recent evidence suggests that B‐and T‐cell interactions may be paramount in relapsing‐
remitting MS (RRMS) disease pathogenesis. We hypothesized that memory B‐cell pools …

Multiple sclerosis (MS) is a chronic demyelinating disorder of unknown etiology, possibly
caused by a virus or virus-triggered immunopathology. The virus might reactivate after years …

Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease
of the central nervous system of uncertain etiology. There is consensus that a dysregulated …