[HTML][HTML] Developing recombinant antibodies by phage display against infectious diseases and toxins for diagnostics and therapy

KDR Roth, EV Wenzel, M Ruschig, S Steinke… - Frontiers in cellular …, 2021 - frontiersin.org
Antibodies are essential molecules for diagnosis and treatment of diseases caused by
pathogens and their toxins. Antibodies were integrated in our medical repertoire against …

Human infection with highly pathogenic avian influenza A (H5N1) virus: review of clinical issues

TM Uyeki - Clinical infectious diseases, 2009 - academic.oup.com
This article provides an updated review of the clinical issues related to human infection with
highly pathogenic avian influenza A (H5N1) virus. The clinical data available to date are …

Nanobodies with in vitro neutralizing activity protect mice against H5N1 influenza virus infection

LI Ibanez, M De Filette, A Hultberg… - Journal of Infectious …, 2011 - academic.oup.com
Influenza A virus infections impose a recurrent and global disease burden. Current antivirals
against influenza are not always effective. We assessed the protective potential of …

Recombinant antibodies for diagnostics and therapy against pathogens and toxins generated by phage display

P Kuhn, V Fühner, T Unkauf… - PROTEOMICS …, 2016 - Wiley Online Library
Antibodies are valuable molecules for the diagnostic and treatment of diseases caused by
pathogens and toxins. Traditionally, these antibodies are generated by hybridoma …

[HTML][HTML] Discovery of antivirals using phage display

E Sokullu, MS Gauthier, B Coulombe - Viruses, 2021 - mdpi.com
The latest coronavirus disease outbreak, COVID-19, has brought attention to viral infections
which have posed serious health threats to humankind throughout history. The rapid global …

[HTML][HTML] Single chain fragment variable (scFv) antibodies targeting the spike protein of porcine epidemic diarrhea virus provide protection against viral infection in …

F Zhang, Y Chen, Y Ke, L Zhang, B Zhang, L Yang… - Viruses, 2019 - mdpi.com
Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes
severe diarrhea and death in neonatal piglets. Passive immunization with neutralizing …

Soluble expression of single-chain variable fragment (scFv) in Escherichia coli using superfolder green fluorescent protein as fusion partner

M Liu, B Wang, F Wang, Z Yang, D Gao… - Applied microbiology …, 2019 - Springer
Single-chain variable fragment (scFv) has great prospect in medical therapies and
diagnostic applications due to its binding affinity and low immunogenicity. However, the …

The highly conserved HA2 protein of the influenza A virus induces a cross protective immune response

JS Lee, MYE Chowdhury, HJ Moon, YK Choi… - Journal of virological …, 2013 - Elsevier
Existing influenza vaccines protect mostly homologous subtypes and acted most effectively
only when well matched to the circulating strain. Immunization with an updated vaccine is …

[HTML][HTML] An RNA-hydrolyzing recombinant minibody prevents both influenza A virus and coronavirus in co-infection models

QXT Luong, PT Hoang, Y Lee, RQ Ayun, K Na… - Scientific Reports, 2024 - nature.com
With the lifting of COVID-19 non-pharmaceutical interventions, the resurgence of common
viral respiratory infections was recorded in several countries worldwide. It facilitates viral co …

[HTML][HTML] Evolution of therapeutic antibodies, influenza virus biology, influenza, and influenza immunotherapy

U Chaisri, W Chaicumpa - BioMed research international, 2018 - hindawi.com
This narrative review article summarizes past and current technologies for generating
antibodies for passive immunization/immunotherapy. Contemporary DNA and protein …