For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Multisystem inflammatory syndrome in children (MIS-C) is a life-threatening post-infectious
complication occurring unpredictably weeks after mild or asymptomatic SARS-CoV-2 …

Understanding the drivers and markers of clonally expanding HIV-1-infected CD4+ T cells is
essential for HIV-1 eradication. We used single-cell ECCITE-seq, which captures surface …

Epstein–Barr virus (EBV) infection precedes multiple sclerosis (MS) pathology and cross-
reactive antibodies might link EBV infection to CNS autoimmunity. As an altered anti-EBV T …

The immune system plays a significant role in multiple sclerosis. While MS was historically
thought to be T cell-mediated, multiple pieces of evidence now support the view that B cells …

The increasing availability of single-cell data revolutionizes the understanding of biological
mechanisms at cellular resolution. For differential expression analysis in multi-subject single …

Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …

Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …