Multiple sclerosis (MS) is a chronic and often disabling autoimmune disease of the central
nervous system (CNS). Cerebrospinal fluid (CSF) surrounds and protects the CNS. Analysis …

Functional magnetic resonance imaging (fMRI) data is collected in millions of noisy,
redundant dimensions. To understand how different brains process the same stimulus, we …

Autoimmune and inflammatory diseases are polygenic disorders of the immune system.
Many genomic loci harbor risk alleles for several diseases, but the limited resolution of …

The central nervous system HIV reservoir is incompletely understood and is a major barrier
to HIV cure. We profiled people with HIV (PWH) and uninfected controls through single-cell …

Background Gene expression is regulated by transcription factors, cofactors, and epigenetic
mechanisms. Coexpressed genes indicate similar functional categories and gene networks …

The CNS has traditionally been considered an immune privileged site, but is now
understood to have a system of immune surveillance, predominantly involving CD4+ T-cells …

Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by
inflammation and autoimmune responses. This review explores the participation of T cells …

Multiple sclerosis (MS) is a common chronic autoimmune disorder of the central nervous
system that predominantly affects young adults. Mounting evidence indicates that …

Highlights•Advances in multiomics expand the modalities that can be detected in single
cells.•Single-cell omics truly unravel the complexity of the immune system.•Transitioning into …

Background and Objectives New-onset refractory status epilepticus (NORSE) occurs in
previously healthy children or adults, often followed by refractory epilepsy and poor …