Targeting epigenetics: A novel promise for Alzheimer's disease treatment

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

[HTML][HTML] Roles of non-coding RNA in alzheimer's disease pathophysiology

EO Olufunmilayo, RMD Holsinger - International journal of molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is accompanied by
deficits in memory and cognitive functions. The disease is pathologically characterised by …

[HTML][HTML] Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of Biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

Neurodevelopmental toxicity induced by PM2. 5 Exposure and its possible role in Neurodegenerative and mental disorders

X Liu, J Huang, C Song, T Zhang… - Human & …, 2023 - journals.sagepub.com
Recent extensive evidence suggests that ambient fine particulate matter (PM2. 5, with an
aerodynamic diameter≤ 2.5 μm) may be neurotoxic to the brain and cause central nervous …

[HTML][HTML] Posttranscriptional regulation of insulin resistance: implications for metabolic diseases

A Pérez-García, M Torrecilla-Parra… - Biomolecules, 2022 - mdpi.com
Insulin resistance defines an impairment in the biologic response to insulin action in target
tissues, primarily the liver, muscle, adipose tissue, and brain. Insulin resistance affects …

[HTML][HTML] Epigenetic peripheral biomarkers for early diagnosis of Alzheimer's disease

C Villa, A Stoccoro - Genes, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and represents the
leading cause of cognitive impairment and dementia in older individuals throughout the …

[HTML][HTML] Circulating long non-coding RNAs as novel diagnostic biomarkers for Alzheimer's disease (AD): A systematic review and meta-analysis

P Shobeiri, S Alilou, M Jaberinezhad, F Zare, N Karimi… - PloS one, 2023 - journals.plos.org
Background Long non-coding RNAs (lncRNAs) have been reported to be involved in the
pathogenesis of neurodegenerative diseases. It has also been hypothesized that plasma …

Posttranscriptional regulation of Nrf2 through miRNAs and their role in Alzheimer's disease

RK Kaundal, AK Datusalia, SS Sharma - Pharmacological research, 2022 - Elsevier
The nuclear factor erythroid-derived 2-related factor 2 (NFE2L2/Nrf2) is a pivotal facilitator of
cytoprotective responses against the oxidative/electrophilic insults. Upon activation, Nrf2 …

[HTML][HTML] Long non-coding RNAs, extracellular vesicles and inflammation in Alzheimer's disease

A Canseco-Rodriguez, V Masola, V Aliperti… - International Journal of …, 2022 - mdpi.com
Alzheimer's Disease (AD) has currently no effective treatment; however, preventive
measures have the potential to reduce AD risk. Thus, accurate and early prediction of risk is …

[HTML][HTML] LncRNAs as the regulators of brain function and therapeutic targets for Alzheimer's disease

Y Liu, X Chen, Y Che, H Li, Z Zhang, W Peng… - Aging and …, 2022 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common type of dementia and a serious threat to the
health and safety of the elderly population. It has become an emerging public health …