Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling
molecule in the cardiovascular and nervous systems. The production of H2S from l-cysteine …

Mitochondria are important generators of energy, providing ATP through oxidative
phosphorylation. However, mitochondria also monitor complex information from the …

Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …

INTRODUCTION: Hydrogen sulfide is produced endogenously in response to myocardial
ischemia and thought to be cardioprotective. The mechanism underlying this protection has …

It is well known that the biological and carcinogenic effects of 17β-estradiol (E2) are
mediated via nuclear estrogen receptors (ERs) by regulating nuclear gene expression …

Naringenin (NAR), flavonoid abundant in the genus Citrus, has been reported to interact
with the large-conductance calcium-activated potassium channels (BK). Since activators of …

The management of acute heart failure syndromes (AHFS) focuses primarily on improving
hemodynamic function and alleviating symptoms. Emerging evidence has raised the …

Several randomized trials and meta-analyses have shown that primary angioplasty is
superior to thrombolysis in the treatment of ST-segment elevation myocardial infarction (MI) …

Doxorubicin is a chemotherapeutic drug used to treat solid and haematopoietic tumours. Its
use is limited by a major side effect of cardiotoxicity. It was reported that doxorubicin …

Background Adenosine triphosphate-sensitive potassium (KATP) channels in brain are
involved in neuroprotective mechanisms. Pharmacologic activation of these channels is …