Post-traumatic knee osteoarthritis; the role of inflammation and hemarthrosis on disease progression

BJ Evers, MHJ Van Den Bosch, AB Blom… - Frontiers in …, 2022 - frontiersin.org
Knee injuries such as anterior cruciate ligament ruptures and meniscal injury are common
and are most frequently sustained by young and active individuals. Knee injuries will lead to …

Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females

IA Szilagyi, JH Waarsing, D Schiphof… - …, 2022 - academic.oup.com
Objectives The aim of this study was to identify sex-specific prevalence and strength of risk
factors for the incidence of radiographic knee OA (incRKOA). Methods Our study population …

[HTML][HTML] Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for …

Y Hashimoto, Y Nishida, S Takahashi, H Nakamura… - Regenerative …, 2019 - Elsevier
Introduction To investigate the efficacy of the transplantation of autologous bone marrow-
derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) …

Anti-inflammatory therapeutic approaches to prevent or delay post-traumatic osteoarthritis (PTOA) of the knee joint with a focus on sustained delivery approaches

CM Khella, JM Horvath, R Asgarian, B Rolauffs… - International Journal of …, 2021 - mdpi.com
Inflammation plays a central role in the pathogenesis of knee PTOA after knee trauma. While
a comprehensive therapy capable of preventing or delaying post-traumatic osteoarthritis …

Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative

JB Driban, CB Eaton, GH Lo, RJ Ward… - Arthritis care & …, 2014 - Wiley Online Library
Objective We aimed to evaluate whether a recent knee injury was associated with
accelerated knee osteoarthritis (OA) progression. Methods In the Osteoarthritis Initiative, we …

The rising incidence of degenerative and posttraumatic osteoarthritis of the knee in the United States military

JE Showery, NA Kusnezov, JC Dunn, JO Bader… - The Journal of …, 2016 - Elsevier
Background This investigation sought to quantify incidence rates (IRs) and risk factors for
primary and secondary (ie, posttraumatic) osteoarthritis (OA) of the knee in an active military …

Environmental risk factors for osteoarthritis: The impact on individuals with knee joint injury

DM Werner, YM Golightly, M Tao… - Rheumatic …, 2022 - rheumatic.theclinics.com
Discussion Risk factors for the development and progression of early knee OA can be
broken into two categories: non-modifiable and modifiable (Table 1). Non-modifiable risk …

Targeted treatment for osteoarthritis: drugs and delivery system

L Mao, W Wu, M Wang, J Guo, H Li, S Zhang, J Xu… - Drug …, 2021 - Taylor & Francis
The management of osteoarthritis (OA) is a clinical challenge due to the particular avascular,
dense, and occluded tissue structure. Despite numerous clinical reports and animal studies …

Pre-osteoarthritis: definition and diagnosis of an elusive clinical entity

L Ryd, M Brittberg, K Eriksson, JS Jurvelin… - Cartilage, 2015 - journals.sagepub.com
Objective An attempt to define pre-osteoarthritis (OA) versus early OA and definitive
osteoarthritis. Methods A group of specialists in the field of cartilage science and treatment …

[HTML][HTML] Osteoarthritis-related biomarkers following anterior cruciate ligament injury and reconstruction: a systematic review

MS Harkey, BA Luc, YM Golightly, AC Thomas… - Osteoarthritis and …, 2015 - Elsevier
Objective There is an increased risk of developing knee osteoarthritis (OA) following anterior
cruciate ligament (ACL) injury. Biomarkers may provide diagnostic, prognostic, or burden of …