International Union of Basic and Clinical Pharmacology. CX. Classification of receptors for 5-hydroxytryptamine; pharmacology and function
5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …
therapeutics and various drugs in development. Their diversity of structure and function …
DREADDs for neuroscientists
BL Roth - Neuron, 2016 - cell.com
To understand brain function, it is essential that we discover how cellular signaling specifies
normal and pathological brain function. In this regard, chemogenetic technologies represent …
normal and pathological brain function. In this regard, chemogenetic technologies represent …
Structure-based discovery of nonhallucinogenic psychedelic analogs
D Cao, J Yu, H Wang, Z Luo, X Liu, L He, J Qi, L Fan… - Science, 2022 - science.org
Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …
Structural insights into the lipid and ligand regulation of serotonin receptors
Abstract Serotonin, or 5-hydroxytryptamine (5-HT), is an important neurotransmitter, that
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …
activates the largest subtype family of G-protein-coupled receptors. Drugs that target 5 …
ProLIF: a library to encode molecular interactions as fingerprints
C Bouysset, S Fiorucci - Journal of cheminformatics, 2021 - Springer
Interaction fingerprints are vector representations that summarize the three-dimensional
nature of interactions in molecular complexes, typically formed between a protein and a …
nature of interactions in molecular complexes, typically formed between a protein and a …
[HTML][HTML] Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs
Cancer is the second leading cause of death worldwide and patients are in urgent need of
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …
Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells
Background Bifidobacterium longum subsp. infantis (B. infantis) is a commensal bacterium
that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize …
that colonizes the gastrointestinal tract of breast-fed infants. B. infantis can efficiently utilize …
How ligands illuminate GPCR molecular pharmacology
G protein-coupled receptors (GPCRs), which are modulated by a variety of endogenous and
synthetic ligands, represent the largest family of druggable targets in the human genome …
synthetic ligands, represent the largest family of druggable targets in the human genome …
GPCR dynamics: structures in motion
The function of G protein-coupled receptors (GPCRs) which represent the largest class of
both human membrane proteins and drug targets depends critically on their ability to …
both human membrane proteins and drug targets depends critically on their ability to …
[HTML][HTML] Crystal structure of an LSD-bound human serotonin receptor
The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the
crystal structure of LSD in complex with the human serotonin receptor 5-HT 2B. The complex …
crystal structure of LSD in complex with the human serotonin receptor 5-HT 2B. The complex …