The Mediator complex controls RNA polymerase II (pol II) activity by coordinating the
assembly of pol II regulatory factors at transcription start sites and by mediating interactions …

Spina bifida is the most common congenital defect of the central nervous system which can
portend lifelong disability to those afflicted. While the complete underpinnings of this disease …

Neural tube defects (NTDs) are a classic example of preventable birth defects for which
there is a proven‐effective intervention, folic acid (FA); however, further methods of …

Neural tube closure (NTC) is crucial for proper development of the brain and spinal cord and
requires precise morphogenesis from a sheet of cells to an intact three‐dimensional …

During neural tube closure, neural ectoderm cells constrict their apical surfaces to bend and
fold the tissue into a tube that will become the central nervous system. Recent data from …

Neural tube defects (NTDs) represent a prevalent and severe category of congenital
anomalies in humans. Cadmium (Cd) is an environmental teratogen known to cause fetal …

The MED13L-related intellectual disability or MRFACD syndrome (Mental retardation and
distinctive facial features with or without cardiac defects; MIM# 616789) is one of the most …

目的综述脊柱裂的病因及发病机制等研究进展. 方法通过查阅国内外脊柱裂相关研究文献,
从分型, 流行趋势, 发病机制, 病因及预防治疗等方面进行分析, 归纳和总结. 结果脊柱裂是神经管 …

During neural tube closure, neural ectoderm cells constrict their apical surfaces to bend and
fold the tissue into a tube that will become the central nervous system. These cells are …

Neural tube defects (NTDs) are common birth defects with a complex genetic etiology.
Mouse genetic models have indicated a number of candidate genes, of which functional …