Acute myocardial infarction (AMI) is the leading cause of death worldwide. Its associated
mortality, morbidity and complications have significantly decreased with the development of …

Nitric oxide (NO) is synthesized by at least three distinct isoforms of NO synthase (NOS).
Their substrate and cofactor requirements are very similar. All three isoforms have some …

Evidence suggests that endothelial dysfunction is on the causal pathway for both
atherogenesis and destabilization of established plaques. In this review, the role of flow …

Endothelium-derived nitric oxide (EDNO) is a pivotal molecule in the regulation of vascular
tone via the stimulation of vascular smooth muscle cell relaxation and concomitant …

Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-
dominant polycystic kidney disease. Background Patients with autosomal-dominant …

Objective To obtain further insight into the mechanism underlying the vasodilator effect of
nebivolol. Since oxidative inactivation of nitric oxide (NO) is regarded as an important cause …

Nitric oxide (NO) is formed enzymatically from l‐arginine in the presence of nitric oxide
synthase (NOS). Nitric oxide is generated constitutively in endothelial cells via sheer stress …

Interest in the endothelium has been growing in recent decades and the traditional belief
that it provides an inert interface between blood and the vessel wall is no longer the case. It …

Background: The bases for the association between sleep-disordered breathing (SDB) and
cardiovascular disease are poorly understood. Endothelial dysfunction, assessed with …

New evidence from recently completed clinical studies performed with nebivolol, a highly
selective beta‐1 β‐blocker, endowed with additional vasodilating activity mediated by nitric …