Rho GTPases are key molecular switches controlling the transduction of external signals to
cytoplasmic and nuclear effectors. In the last few years, the development of genetic and …

CDKL5 deficiency disorder (CDD) is an X-linked brain disorder of young children and is
caused by pathogenic variants in the cyclin-dependent kinase-like 5 (CDKL5) gene …

Fasting triggers diverse physiological adaptations including increases in circulating fatty
acids and mitochondrial respiration to facilitate organismal survival. The mechanisms driving …

IL‐1β can exit the cytosol as an exosomal cargo following inflammasome activation in
intestinal epithelial cells (IECs) in a Gasdermin D (GSDMD)‐dependent manner. The …

Simple Summary IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a signal
scaffolding protein that regulates a range of cellular activities by facilitating signal …

The assembly of HIV-1 particles is a concerted and dynamic process that takes place on the
plasma membrane of infected cells. An abundance of recent discoveries has advanced our …

Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface
that control a myriad of cellular functions despite their low abundance among phospholipids …

ABSTRACT The lipid molecule phosphatidylinositol (4, 5)-bisphosphate [PI (4, 5) P 2]
controls all aspects of plasma membrane (PM) function in animal cells, from its selective …

HIV-1 has evolved a plethora of strategies to overcome the cytoskeletal barrier (ie, actin and
intermediate filaments (AFs and IFs) and microtubules (MTs)) to achieve the viral cycle. HIV …

Tumour‐derived microvesicles (MVs) serve as critical mediators of cell‐to‐cell
communication in the tumour microenvironment. So far, the underlying mechanisms of MV …