Cancer targeting peptides

M Kalmouni, S Al-Hosani, M Magzoub - Cellular and Molecular Life …, 2019 - Springer
Despite continuing advances in the development of biomacromolecules for therapeutic
purposes, successful application of these often large and hydrophilic molecules has been …

[HTML][HTML] Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain

A Sharma, DC Fernandes, RL Reis, D Gołubczyk… - Cell & Bioscience, 2023 - Springer
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required
for maintaining the executive functions of the central nervous system (CNS). Tight control of …

[HTML][HTML] IL-26, a cytokine with roles in extracellular DNA-induced inflammation and microbial defense

V Larochette, C Miot, C Poli, E Beaumont… - Frontiers in …, 2019 - frontiersin.org
Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily,
and is a novel mediator of inflammation overexpressed in activated or transformed T cells …

Application of computational approaches in biomembranes: From structure to function

J Guo, Y Bao, M Li, S Li, L Xi, P Xin… - Wiley …, 2023 - Wiley Online Library
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …

[HTML][HTML] Targeting the 'Undruggable'Driver protein, KRAS, in epithelial cancers: Current perspective

KK Lam, SH Wong, PY Cheah - Cells, 2023 - mdpi.com
This review summarizes recent development in synthetic drugs and biologics targeting
intracellular driver genes in epithelial cancers, focusing on KRAS, and provides a current …

[HTML][HTML] Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K

J Macyszyn, P Chyży, M Burmistrz, M Lobka… - Scientific Reports, 2023 - nature.com
Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …

Melittin ameliorates endotoxin‐induced acute kidney injury by inhibiting inflammation, oxidative stress, and cell death in mice

JY Kim, J Leem, HL Hong - Oxidative medicine and cellular …, 2021 - Wiley Online Library
Sepsis‐related acute kidney injury (AKI) is a worldwide health problem, and its
pathogenesis involves multiple pathways. Lipopolysaccharide (LPS) is an endotoxin that …

[HTML][HTML] Electrochemical peptide-based sensors for foodborne pathogens detection

M Tertis, O Hosu, B Feier, A Cernat, A Florea, C Cristea - Molecules, 2021 - mdpi.com
Food safety and quality control pose serious issues to food industry and public health
domains, in general, with direct effects on consumers. Any physical, chemical, or biological …

[HTML][HTML] Alternative antibiotics in dentistry: Antimicrobial peptides

A Griffith, A Mateen, K Markowitz, SR Singer, C Cugini… - Pharmaceutics, 2022 - mdpi.com
The rise of antibiotic resistant bacteria due to overuse and misuse of antibiotics in medicine
and dentistry is a growing concern. New approaches are needed to combat antibiotic …

Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds

W Mitchell, JD Tamucci, EL Ng, S Liu, AV Birk… - Elife, 2022 - elifesciences.org
Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle
underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with …