Cancer targeting peptides
M Kalmouni, S Al-Hosani, M Magzoub - Cellular and Molecular Life …, 2019 - Springer
Despite continuing advances in the development of biomacromolecules for therapeutic
purposes, successful application of these often large and hydrophilic molecules has been …
purposes, successful application of these often large and hydrophilic molecules has been …
[HTML][HTML] Cutting-edge advances in modeling the blood–brain barrier and tools for its reversible permeabilization for enhanced drug delivery into the brain
The blood–brain barrier (BBB) is a sophisticated structure whose full functionality is required
for maintaining the executive functions of the central nervous system (CNS). Tight control of …
for maintaining the executive functions of the central nervous system (CNS). Tight control of …
[HTML][HTML] IL-26, a cytokine with roles in extracellular DNA-induced inflammation and microbial defense
V Larochette, C Miot, C Poli, E Beaumont… - Frontiers in …, 2019 - frontiersin.org
Interleukin 26 (IL-26) is the most recently identified member of the IL-20 cytokine subfamily,
and is a novel mediator of inflammation overexpressed in activated or transformed T cells …
and is a novel mediator of inflammation overexpressed in activated or transformed T cells …
Application of computational approaches in biomembranes: From structure to function
J Guo, Y Bao, M Li, S Li, L Xi, P Xin… - Wiley …, 2023 - Wiley Online Library
Biological membranes (biomembranes) are one of the most complicated structures that
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
allow life to exist. Investigating their structure, dynamics, and function is crucial for advancing …
[HTML][HTML] Targeting the 'Undruggable'Driver protein, KRAS, in epithelial cancers: Current perspective
This review summarizes recent development in synthetic drugs and biologics targeting
intracellular driver genes in epithelial cancers, focusing on KRAS, and provides a current …
intracellular driver genes in epithelial cancers, focusing on KRAS, and provides a current …
[HTML][HTML] Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K
J Macyszyn, P Chyży, M Burmistrz, M Lobka… - Scientific Reports, 2023 - nature.com
Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …
peptide (KFF) 3K to transform it into an antibacterial peptide. Namely, we inserted a …
Melittin ameliorates endotoxin‐induced acute kidney injury by inhibiting inflammation, oxidative stress, and cell death in mice
JY Kim, J Leem, HL Hong - Oxidative medicine and cellular …, 2021 - Wiley Online Library
Sepsis‐related acute kidney injury (AKI) is a worldwide health problem, and its
pathogenesis involves multiple pathways. Lipopolysaccharide (LPS) is an endotoxin that …
pathogenesis involves multiple pathways. Lipopolysaccharide (LPS) is an endotoxin that …
[HTML][HTML] Electrochemical peptide-based sensors for foodborne pathogens detection
Food safety and quality control pose serious issues to food industry and public health
domains, in general, with direct effects on consumers. Any physical, chemical, or biological …
domains, in general, with direct effects on consumers. Any physical, chemical, or biological …
[HTML][HTML] Alternative antibiotics in dentistry: Antimicrobial peptides
A Griffith, A Mateen, K Markowitz, SR Singer, C Cugini… - Pharmaceutics, 2022 - mdpi.com
The rise of antibiotic resistant bacteria due to overuse and misuse of antibiotics in medicine
and dentistry is a growing concern. New approaches are needed to combat antibiotic …
and dentistry is a growing concern. New approaches are needed to combat antibiotic …
Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds
W Mitchell, JD Tamucci, EL Ng, S Liu, AV Birk… - Elife, 2022 - elifesciences.org
Mitochondria play a central role in metabolic homeostasis, and dysfunction of this organelle
underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with …
underpins the etiology of many heritable and aging-related diseases. Tetrapeptides with …