Effect of central PxxP motif in amphipathic alpha-helical peptides on antimicrobial activity and mode of action

H Lee, S Yang, SH Shin - Journal of Analytical Science and Technology, 2023 - Springer
Amphipathic α-helical peptides (AHPs) have shown potential as a therapeutic approach
against multi-drug-resistant bacterial infections due to their broad-spectrum antimicrobial …

Conformational Changes of Anoplin, W-MreB1–9, and (KFF)3K Peptides near the Membranes

M Wojciechowska, J Miszkiewicz, J Trylska - International journal of …, 2020 - mdpi.com
Many peptides interact with biological membranes, but elucidating these interactions is
challenging because cellular membranes are complex and peptides are structurally flexible …

Deuterium solid state NMR studies of intact bacteria treated with antimicrobial peptides

V Booth - Frontiers in Medical Technology, 2021 - frontiersin.org
Solid state NMR has been tremendously useful in characterizing the structure and dynamics
of model membranes composed of simple lipid mixtures. Model lipid studies employing solid …

Lipid II binding and transmembrane properties of various antimicrobial lanthipeptides

R Pokhrel, N Bhattarai, P Baral… - Journal of Chemical …, 2021 - ACS Publications
There has been an alarming rise in antibacterial resistant infections in recent years due to
the widespread use of antibiotics, and there is a dire need for the development of new …

[HTML][HTML] Translational use of homing peptides: Tumor and placental targeting

AA Alobaid, MWA Skoda, LK Harris… - Journal of Colloid and …, 2024 - Elsevier
Hypothesis Tissue-specific homing peptides have been shown to improve chemotherapeutic
efficacy due to their trophism for tumor cells. Other sequences that selectively home to the …

Caerin 1 Peptides, the Potential Jack‐of‐All‐Trades for the Multiple Antibiotic‐Resistant Bacterial Infection Treatment and Cancer Immunotherapy

L Xiao, X Yang, J Li, P Zhang, S Tang… - BioMed Research …, 2022 - Wiley Online Library
Antibiotic resistance‐related bacterial infections and cancers become huge challenges in
human health in the 21st century. A number of naturally derived antimicrobial peptides …

Investigating Penetration and Antimicrobial Activity of Vector-Bicycle Conjugates

A Hadjicharalambous, H Newman, N Lewis… - ACS Infectious …, 2024 - ACS Publications
Growing antibiotic resistance is rapidly threatening the efficacy of treatments for Gram-
negative infections. Bicycle molecules, constrained bicyclic peptides from diverse libraries …

What's the defect? Using mass defects to study oligomerization of membrane proteins and peptides in nanodiscs with native mass spectrometry

JA Townsend, MT Marty - Methods, 2023 - Elsevier
Many membrane proteins form functional complexes that are either homo-or hetero-
oligomeric. However, it is challenging to characterize membrane protein oligomerization in …

The application progress of peptides in drug delivery systems in the past decade

B Yang, T Wang, Y Yang, H Zhu, J Li - Journal of Drug Delivery Science …, 2021 - Elsevier
Peptides are compounds formed by linking 20 natural amino acids through amide bonds,
which widely exist in organisms. Thanks to their excellent biological activity …

Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential

S Lu, J Lin, J Jin, L Zhang, Y Guan, H Chen… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Increasing evidence suggests that intratumor microbiota are an intrinsic
component in the tumor microenvironment across multiple cancer types, and that there is a …