The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

p53 plays a key role in mediating cell response to various stresses, mainly by inducing or
repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA …

Peroxiredoxins (PRDX s), a ubiquitous family of redox‐regulating proteins, are reported of
potential to eliminate various reactive oxygen species (ROS). As a major member of the …

Gene set analysis using biological pathways has become a widely used statistical approach
for gene expression analysis. A biological pathway can be represented through a graph …

Abstract Background Studies link c-Abl activation with the accumulation of pathogenic α-
synuclein (αS) and neurodegeneration in Parkinson's disease (PD). Currently, c-Abl, a …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which
pathogenesis and death of motor neurons are triggered by non-cell-autonomous …

p53 is a vital transcriptional protein implicated in regulating diverse cellular processes,
including cell cycle arrest, DNA repair, mitochondrial metabolism, redox homeostasis …

Control theory is a well-established approach in network science, with applications in bio-
medicine and cancer research. We build on recent results for structural controllability of …

p66Shc is a widely expressed protein that governs a variety of cardiovascular pathologies
by generating, and exacerbating, pro-apoptotic ROS signals. Here, we review p66Shc's …

Two related tumor suppressor genes, BRCA1 and BRCA2, attract a lot of attention from both
fundamental and clinical points of view. Oncogenic hereditary mutations in these genes are …