[HTML][HTML] The role of kisspeptin in the control of the hypothalamic-pituitary-gonadal axis and reproduction

Q Xie, Y Kang, C Zhang, Y Xie, C Wang, J Liu… - Frontiers in …, 2022 - frontiersin.org
The discovery of kisspeptin as a critical central regulatory factor of GnRH release has given
people a novel understanding of the neuroendocrine regulation in human reproduction …

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Y Cao, Z Li, W Jiang, Y Ling, H Kuang - Reproductive Biology and …, 2019 - Springer
Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian
reproduction due to their involvement in the onset of puberty and control of the hypothalamic …

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

KL Hu, HM Chang, HC Zhao, Y Yu… - Human reproduction …, 2018 - academic.oup.com
BACKGROUND Initially identified as suppressors of metastasis in various types of cancer,
kisspeptins are a family of neuropeptides that are key regulators of the mammalian …

The emerging therapeutic potential of kisspeptin and neurokinin B

B Patel, K Koysombat, EG Mills, J Tsoutsouki… - Endocrine …, 2024 - academic.oup.com
Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive
endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) …

Advances in clinical applications of kisspeptin-GnRH pathway in female reproduction

KL Hu, Z Chen, X Li, E Cai, H Yang, Y Chen… - Reproductive Biology …, 2022 - Springer
Background Kisspeptin is the leading upstream regulator of pulsatile and surge
Gonadotrophin-Releasing Hormone secretion (GnRH) in the hypothalamus, which acts as …

[HTML][HTML] Role of kisspeptins in the control of the hypothalamic-pituitary-ovarian axis: old dogmas and new challenges

ST Ruohonen, M Poutanen, M Tena-Sempere - Fertility and Sterility, 2020 - Elsevier
In humans and other mammals, a hallmark of female reproductive function is the capacity to
episodically release fertilizable oocytes under the precise control of a cascade of hormonal …

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

MK Lim, CW Ku, TC Tan, YHJ Lee, JC Allen, NS Tan - Scientific reports, 2020 - nature.com
Progesterone-induced blocking factor (PIBF), which plays an important role in maintaining
healthy pregnancies, has shown great promise as a prognostic biomarker for threatened …

[HTML][HTML] Performance of plasma kisspeptin as a biomarker for miscarriage improves with gestational age during the first trimester

A Abbara, M Al-Memar, M Phylactou, C Kyriacou… - Fertility and …, 2021 - Elsevier
Objective To compare the performance of kisspeptin and beta human chorionic
gonadotropin (βhCG), both alone and in combination, as biomarkers for miscarriage …

Kisspeptin suppresses inflammasome-NLRP3 activation and pyroptosis caused by hypothyroidism at the maternal-fetal interface of rats

BR Santos, JMA Cordeiro, LC Santos… - International Journal of …, 2023 - mdpi.com
Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome
activation and pyroptosis in the placenta and changes in placental kisspeptin levels …

[HTML][HTML] Kisspeptin in the prediction of pregnancy complications

J Tsoutsouki, B Patel, AN Comninos… - Frontiers in …, 2022 - frontiersin.org
Kisspeptin and its receptor are central to reproductive health acting as key regulators of the
reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator …