Engineered bacterial membrane vesicles are promising carriers for vaccine design and tumor immunotherapy

Q Long, P Zheng, X Zheng, W Li, L Hua, Z Yang… - Advanced drug delivery …, 2022 - Elsevier
Bacterial membrane vesicles (BMVs) have emerged as novel and promising platforms for
the development of vaccines and immunotherapeutic strategies against infectious and …

[HTML][HTML] Peptide-based vaccines for tuberculosis

W Gong, C Pan, P Cheng, J Wang, G Zhao… - Frontiers in …, 2022 - frontiersin.org
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. As a
result of the coronavirus disease 2019 (COVID-19) pandemic, the global TB mortality rate in …

Engineering bacterial membrane nanovesicles for improved therapies in infectious diseases and cancer

J Gao, Y Su, Z Wang - Advanced drug delivery reviews, 2022 - Elsevier
Research on bacterial membrane vesicles (BMVs) is an emerging topic, and the goal is to
address whether BMVs can bring translational tools to improve current therapies. In this …

[HTML][HTML] Prophylactic vaccine delivery systems against epidemic infectious diseases

C Pan, H Yue, L Zhu, G Ma, H Wang - Advanced drug delivery reviews, 2021 - Elsevier
Prophylactic vaccines have evolved from traditional whole-cell vaccines to safer subunit
vaccines. However, subunit vaccines still face problems, such as poor immunogenicity and …

[HTML][HTML] Biological nanoparticles in vaccine development

SM Curley, D Putnam - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Vaccines represent one of the most successful public health initiatives worldwide. However,
despite the vast number of highly effective vaccines, some infectious diseases still do not …

Lung resident memory T cells activated by oral vaccination afford comprehensive protection against pneumonic Yersinia pestis infection

AK Singh, S Majumder, X Wang, R Song… - The Journal of …, 2023 - journals.aai.org
A growing body of evidence has shown that resident memory T (T RM) cells formed in tissue
after mucosal infection or vaccination are crucial for counteracting reinfection by pathogens …

[HTML][HTML] Engineered remolding and application of bacterial membrane vesicles

L Qiao, Y Rao, K Zhu, X Rao, R Zhou - Frontiers in Microbiology, 2021 - frontiersin.org
Bacterial membrane vesicles (MVs) are produced by both Gram-positive and Gram-negative
bacteria during growth in vitro and in vivo. MVs are nanoscale vesicular structures with …

Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague

X Wang, P Li, AK Singh, X Zhang… - Proceedings of the …, 2022 - National Acad Sciences
A recombinant enteric Yersinia pseudotuberculosis PB1+ strain (Yptb) was designed to
synthesize an adjuvant form of lipid A (monophosphoryl lipid A [MPLA]), and tailor an Asd+ …

Outer membrane vesicles displaying a heterologous PcrV-HitA fusion antigen promote protection against pulmonary Pseudomonas aeruginosa infection

P Li, X Wang, X Sun, Z Guan, W Sun - Msphere, 2021 - Am Soc Microbiol
Along with surging threats and antibiotic resistance of Pseudomonas aeruginosa in health
care settings, it is imperative to develop effective vaccines against P. aeruginosa infection. In …

[HTML][HTML] Development of a dual antigen lateral flow immunoassay for detecting Yersinia pestis

D Hau, B Wade, C Lovejoy, SG Pandit… - PLOS Neglected …, 2022 - journals.plos.org
Background Yersinia pestis is the causative agent of plague, a zoonosis associated with
small mammals. Plague is a severe disease, especially in the pneumonic and septicemic …