In humans, the S100 protein family is composed of 21 members that exhibit a high degree of
structural similarity, but are not functionally interchangeable. This family of proteins …

S100 is a multigenic family of non-ubiquitous Ca2+-modulated proteins of the EF-hand type
expressed in vertebrates exclusively and implicated in intracellular and extracellular …

Increased numbers of S100A4+ cells are associated with poor prognosis in patients who
have cancer. Although the metastatic capabilities of S100A4+ cancer cells have been …

The calcium-binding protein S100A4 promotes metastasis in several experimental animal
models, and S100A4 protein expression is associated with patient outcome in a number of …

A multigenic family of Ca2+-binding proteins of the EF-hand type known as S100 comprises
19 members that are differentially expressed in a large number of cell types. Members of this …

Metastasis is the leading cause of cancer-related death and directly associates with cancer
progression, resistance to anticancer therapy, and poor patient survival. Current efforts …

S100 protein family has been implicated in multiple stages of tumorigenesis and
progression. Among the S100 genes, 22 are clustered at chromosome locus 1q21, a region …

The transition from benign tumor growth to malignancy is manifested by the ability of tumor
cells to traverse tissue barriers and invade surrounding tissues. The traversal of basement …

The calcium-binding protein S100A4 is capable of inducing metastasis in rodent models for
breast cancer. We now show that rabbit antibodies to recombinant rat S100A4 recognize …

A physical and functional interaction between the Ca 2+-binding protein Mts1 (S100A4) and
the tumor suppressor p53 protein is shown here for the first time. We demonstrate that Mts1 …