Antioxidant defence systems and oxidative stress in poultry biology: An update

PF Surai, II Kochish, VI Fisinin, MT Kidd - Antioxidants, 2019 - mdpi.com
Poultry in commercial settings are exposed to a range of stressors. A growing body of
information clearly indicates that excess ROS/RNS production and oxidative stress are …

Extracellular vesicles from plants: current knowledge and open questions

O Urzì, S Raimondo, R Alessandro - International Journal of Molecular …, 2021 - mdpi.com
The scientific interest in the beneficial properties of natural substances has been recognized
for decades, as well as the growing attention in extracellular vesicles (EVs) released by …

T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10

VM Ravi, N Neidert, P Will, K Joseph, JP Maier… - Nature …, 2022 - nature.com
Despite recent advances in cancer immunotherapy, certain tumor types, such as
Glioblastomas, are highly resistant due to their tumor microenvironment disabling the anti …

Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases

SC Funes, M Rios, A Fernández-Fierro… - Frontiers in …, 2020 - frontiersin.org
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group
degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

Identification of HMOX1 as a critical ferroptosis-related gene in atherosclerosis

D Wu, Q Hu, Y Wang, M Jin, Z Tao… - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Ferroptosis is a novel form of programmed iron-dependent cell death. The ferroptosis-
related genes (FRGs) have been recognized as biomarkers for cancers. Increasing …

Immune response and barrier dysfunction-related proteomic signatures in preclinical phase of Crohn's disease highlight earliest events of pathogenesis

H Leibovitzh, SH Lee, JAR Garay, O Espin-Garcia… - Gut, 2023 - gut.bmj.com
Objective The measure of serum proteome in the preclinical state of Crohn's disease (CD)
may provide insight into biological pathways involved in CD pathogenesis. We aimed to …

impact of cigarette smoking on intestinal inflammation—direct and indirect mechanisms

S Papoutsopoulou, J Satsangi… - Alimentary …, 2020 - Wiley Online Library
Background The inflammatory bowel diseases, Crohn's disease and ulcerative colitis are
related multifactorial diseases. Their pathogenesis is influenced by each individual's …

A targeted proteomics approach reveals a serum protein signature as diagnostic biomarker for resectable gastric cancer

Q Shen, K Polom, C Williams, FMS de Oliveira… - …, 2019 - thelancet.com
Background Gastric cancer (GC) is the third leading cause of cancer death. Early detection
is a key factor to reduce its mortality. Methods We retrospectively collected pre-and …

Musculoskeletal complications associated with pathological iron toxicity and its molecular mechanisms

M Simão, ML Cancela - Biochemical Society Transactions, 2021 - portlandpress.com
Iron is fundamental for several biological functions, but when in excess can lead to the
development of toxic events. Some tissues and cells are more susceptible than others, but …