Arbutin ameliorates hyperglycemia, dyslipidemia and oxidative stress and modulates adipocytokines and PPARγ in high-fat diet/streptozotocin-induced diabetic rats

MS Abduh, MA Alzoghaibi, AM Alzoghaibi… - Life Sciences, 2023 - Elsevier
Arbutin is a glycosylated hydroquinone with antioxidant and anti-hyperglycemia effects.
However, its beneficial effects in type 2 diabetes (T2D) were not clarified. This study …

Determination of Arbutin in Vitro and in Vivo by LC-MS/MS: Pre-clinical Evaluation of Natural Product Arbutin for its early Medicinal Properties

QL Wang, PX Zhang, M Xu, L Han, X Shi… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Arbutin is a naturally occurring glucoside extracted from
plants, known for its antioxidant and tyrosinase inhibiting properties.. It is widely used in …

Protective effect of arbutin against cyclophosphamide-induced oxidative stress, inflammation, and hepatotoxicity via Nrf2/HO-1 pathway in rats

RS Alruhaimi - Environmental Science and Pollution Research, 2023 - Springer
Cyclophosphamide (CP) is a potent anticancer drug widely employed in chemotherapy
against various types of cancer. However, CP leads to toxicity to non-targeted organs …

Arbutin abrogates cisplatin-induced hepatotoxicity via upregulating Nrf2/HO-1 and suppressing genotoxicity, NF-κB/iNOS/TNF-α and caspase-3/Bax/Bcl2 signaling …

IF Okkay, A Famurewa, C Bayram, U Okkay… - Toxicology …, 2024 - academic.oup.com
Background: Cisplatin is a potent anticancer agent widely employed in chemotherapy.
However, cisplatin leads to toxicity on non-targeted healthy organs, including the liver. We …

Antibacterial effectiveness of trans-cinnamaldehyde against foodborne Enterobacteriaceae and its adjuvant effect with gentamicin

BF da Silva, AMG Pereira, PAT Coelho… - Brazilian Journal of …, 2024 - Springer
The Enterobacteriaceae family is recognized as a primary group of Gram-negative
pathogens responsible for foodborne illnesses and is frequently associated with antibiotic …

[PDF][PDF] Investigation of Possible Positive Effects of Arbutin Application in Experimental Colitis Model

MB Alemdar, F Şirinyıldız, A Coşkun, İ Meteoğlu… - 2024 - turkjgastroenterol.org
ABSTRACT Background/Aims: This study aimed to investigate the possible positive effects
of arbutin in a trinitrobenzene sulfonic acid (TNBS)-induced experimental colitis model, to …