Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …

Cyclooxygenases-2 (COX-2) and Prostaglandin E2 (PGE2), which are important in chronic
inflammatory diseases, can increase tumor incidence and promote tumor growth and …

Cytotoxic therapies, besides directly inducing cancer cell death, can stimulate immune-
dependent tumor growth control or paradoxically accelerate tumor progression. The …

Although viral hepatocellular carcinoma (HCC) is declining, nonviral HCC, which often is the
end stage of nonalcoholic or alcoholic steatohepatitis (NASH, ASH), is on an upward …

Abstract Background Cancer-associated fibroblasts (CAFs) are critically involved in tumor
progression by maintaining extracellular mesenchyma (ECM) production and improving …

Chemoprevention refers to the use of natural or synthetic agents to reverse, suppress, or
prevent the progression or recurrence of cancer. A large body of preclinical and clinical data …

The body's normal immune response against any invading pathogen that causes infection in
the body results in inflammation. The sudden transformation in inflammation leads to the rise …

Inflammation has accompanied human beings since the emergence of wounds and
infections. In the past decades, numerous efforts have been undertaken to explore the …

The mechanisms underlying the regulation of a checkpoint receptor, PD-1, in tumor-
infiltrating immune cells during the development of colorectal cancer are not fully …

Backgrounds In inflammatory bowel disease microenvironment, transdifferentiation of
myeloidderived suppressor cells (MDSCs) and M2 macrophage accumulation are crucial for …