[HTML][HTML] Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy

Q Zhang, R Xiang, S Huo, Y Zhou, S Jiang… - Signal transduction and …, 2021 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in an unprecedented setback …

[HTML][HTML] COVID-19: breaking down a global health crisis

SI Mallah, OK Ghorab, S Al-Salmi, OS Abdellatif… - Annals of clinical …, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is the second pandemic of the twenty-first
century, with over one-hundred million infections and over two million deaths to date. It is a …

Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence

S Rahman, MTV Montero, K Rowe… - Expert review of …, 2021 - Taylor & Francis
Introduction The COVID-19 pandemic has created a public health crisis, infected millions of
people, and caused a significant number of deaths. SARS-CoV-2 transmits from person to …

[HTML][HTML] A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

Y Zhu, F Feng, G Hu, Y Wang, Y Yu, Y Zhu… - Nature …, 2021 - nature.com
The global spread of SARS-CoV-2 is posing major public health challenges. One feature of
SARS-CoV-2 spike protein is the insertion of multi-basic residues at the S1/S2 subunit …

[HTML][HTML] Furin inhibitors block SARS-CoV-2 spike protein cleavage to suppress virus production and cytopathic effects

YW Cheng, TL Chao, CL Li, MF Chiu, HC Kao… - Cell reports, 2020 - cell.com
Development of specific antiviral agents is an urgent unmet need for SARS-coronavirus 2
(SARS-CoV-2) infection. This study focuses on host proteases that proteolytically activate …

The genetic structure of SARS‐CoV‐2 does not rule out a laboratory origin: SARS‐COV‐2 chimeric structure and furin cleavage site might be the result of genetic …

R Segreto, Y Deigin - Bioessays, 2021 - Wiley Online Library
Severe acute respiratory syndrome‐coronavirus (SARS‐CoV)‐2′ s origin is still
controversial. Genomic analyses show SARS‐CoV‐2 likely to be chimeric, most of its …

[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …

[HTML][HTML] SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

[HTML][HTML] The taxonomy, host range and pathogenicity of coronaviruses and other viruses in the Nidovirales order

Z Zhou, Y Qiu, X Ge - Animal Diseases, 2021 - Springer
The frequent emergence of coronavirus (CoV) epidemics has seriously threatened public
health and stock farming. The major hosts for CoVs are birds and mammals. Although most …

The role of artificial intelligence in tackling COVID-19

N Arora, AK Banerjee, ML Narasu - Future Virology, 2020 - Taylor & Francis
The past two decades were marked with the outbreaks of many viral diseases such as
Chikungunya, Ebola, Zika, Nipah, H7N9 Bird flu, H1N1, SARS and MERS. The world woke …