Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …

There is accumulating evidence to suggest that IgE plays a significant role in autoimmunity.
The presence of circulating self-reactive IgE in patients with autoimmune disorders has been …

Background Epidermolysis bullosa acquisita (EBA) is an orphan autoimmune disease.
Several clinical phenotypes have been described, but subepidermal blistering is …

Intravenous immunoglobulin (IVIg) therapy is widely used to treat a variety of autoimmune
diseases including immunothrombocytopenia, chronic inflammatory demyelinating …

Background: In major depressive disorder (MDD), findings include hyperstable regulation of
brain arousal measured by electroencephalography (EEG) vigilance analysis and …

Bullous pemphigoid, mucous membrane pemphigoid and epidermolysis bullosa acquisita
are subepidermal autoimmune blistering diseases whose antigenic target is located at the …

In orchestrating the wound healing process, the immune system plays a critical role. Hence,
controlling the immune system to repair skin defects is an attractive approach. The highly …

Host defense against pathogens relies on neutrophil activation. Inadequate neutrophil
activation is often associated with chronic inflammatory diseases. Neutrophils also constitute …

IgE has long been known as a therapeutic target for allergic disease, but the difficulty has
been in selecting agents that don't trigger cross linkage of IgE when bound to its high affinity …

T cells are key players in autoimmune diseases by supporting the production of
autoantibodies. However, their contribution to the effector phase of antibody-mediated …