COVID-19, initially regarded as specific lung disease, exhibits an extremely broad spectrum
of symptoms. Extrapulmonary manifestations of the disease also include important …

Astrocytes are increasingly recognized as important viral host cells in the central nervous
system. These cells can produce relatively high quantities of new virions. In part, this can be …

Our lab previously established that metformin, a first-line type two diabetes treatment,
activates the Nrf2 pathway and improves post-stroke recovery. Metformin's brain …

Electronic nicotine delivery systems (ENDS), also commonly known as electronic cigarettes
(e-cigs) are considered in most cases as a safer alternative to tobacco smoking and …

Chronic obstructive pulmonary disease (COPD) is a major incurable health burden, ranking
as the third leading cause of death worldwide, mainly driven by cigarette smoking. COPD is …

Purpose There is growing interest in seeking pharmacological activation of neurolysin (Nln)
for stroke treatment. Discovery of central nervous system drugs remains challenging due to …

COVID-19 is a spectrum of clinical symptoms in humans caused by infection with SARS-CoV-
2. The coalescence of SARS-CoV-2 with seasonal respiratory viruses, particularly influenza …

An imbalance in the circulatory and organ-specific renin-angiotensin system (RAS)
pathways is associated with age-related dysfunction and disease including cardiovascular …

SARS-CoV-2 primarily infects the lungs via the ACE2 receptor but also other organs
including the kidneys, the gastrointestinal tract, the heart, and the skin. SARS-CoV-2 also …

Depression is a highly prevalent psychological disorder characterized by persistent
dysphoria, psychomotor retardation, insomnia, anhedonia, suicidal ideation, and a …