The role of suppressors of cytokine signalling in human neoplasms

W Sasi, AK Sharma, K Mokbel - Molecular biology international, 2014 - Wiley Online Library
Suppressors of cytokine signalling 1–7 (SOCS1–7) and cytokine‐inducible SH2‐containing
protein (CIS) are a group of intracellular proteins that are well known as JAK‐STAT and …

SOCS2 is critical for the balancing of immune response and oxidate stress protecting against acetaminophen-induced acute liver injury

R Monti-Rocha, A Cramer, P Gaio Leite… - Frontiers in …, 2019 - frontiersin.org
Acetaminophen (APAP) is usually safe when administrated in therapeutic doses; however,
APAP overdose can lead to severe liver injury. APAP can cause direct hepatocyte damage …

Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player

RT Uren, AM Turnley - Frontiers in molecular neuroscience, 2014 - frontiersin.org
The classic neurotrophins Nerve Growth Factor (NGF), Brain Derived Neurotrophic Factor
(BDNF) and Neurotrophins NT-3 and NT-4 are well known to regulate various aspects of …

Cytological Ki-67 in pancreatic endocrine tumours: an opportunity for pre-operative grading

C Piani, GM Franchi, C Cappelletti… - Endocrine-Related …, 2008 - erc.bioscientifica.com
Deregulation of cytokine and growth factor signaling due to an altered expression of
endogenous regulators is well recognized in prostate cancer (PCa) and other cancers …

Understanding the role of SOCS signaling in neurodegenerative diseases: Current and emerging concepts

A Cianciulli, R Calvello, C Porro, T Trotta… - Cytokine & growth factor …, 2017 - Elsevier
Suppressor of cytokine signaling proteins (SOCS) are a family of intracellular cytokine
inducible proteins, consisting of eight members. They are involved in the complex control of …

Cytokine-induced SOCS expression is inhibited by cAMP analogue: impact on regeneration in injured retina

KK Park, Y Hu, J Muhling, MA Pollett… - Molecular and Cellular …, 2009 - Elsevier
Injured adult retinal ganglion cells (RGCs) regrow axons into peripheral nerve (PN) grafted
onto cut optic nerve. Survival and regeneration of RGCs is increased by intraocular …

Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A …

M Ramanjaneya, AC Conner, J Chen… - Journal of …, 2009 - joe.bioscientifica.com
We investigated the effect of n-6 polyunsaturated fatty acids (PUFAs) on prostaglandin (PG)
production by the uterus. A mixed population of endometrial cells (epthelium and stroma) …

Metamorphosis and the regenerative capacity of spinal cord axons in Xenopus laevis

KM Gibbs, SV Chittur, BG Szaro - European Journal of …, 2011 - Wiley Online Library
Throughout the vertebrate subphylum, the regenerative potential of central nervous system
axons is greatest in embryonic stages and declines as development progresses. For …

Leptin signaling: A key pathway in immune responses

C Procaccini, EV Lourenco… - Current signal …, 2009 - ingentaconnect.com
Leptin is a hormone whose central role is to regulate endocrine functions and to control
energy expenditure. After the discovery that leptin can also have pro-inflammatory effects …

Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network

D Redelman, LA Welniak, D Taub, WJ Murphy - Cellular immunology, 2008 - Elsevier
Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been
demonstrated to accelerate the recovery of the immune response after chemotherapy and …