Paeoniflorin is a natural monoterpene glycoside in Paeonia lactiflora pall with various
biological properties including promising anti-inflammatory activity. Current evidences …

Toll-like receptor signaling requires interactions of the Toll/IL-1 receptor (TIR) domains of the
receptor and adapter proteins. Using the mammalian protein-protein interaction trap …

Cytokines, such as interferons, erythropoietin, leptin and most interleukins, signal through
type 1 cytokine receptors and activate the canonical JAK–STAT pathway. Aberrant cytokine …

It is well known that Dorper (DP) is a full-bodied, fast-growing and high dressing percentage
breed, while the production performance of Small-tailed Han sheep (STH) is not so …

The suppressors of cytokine signaling (SOCS) family play important roles in regulating a
variety of signal transduction pathways that are involved in immunity, growth and …

Deregulation of cytokine and growth factor signaling due to an altered expression of
endogenous regulators is well recognized in prostate cancer (PCa) and other cancers …

Oxidative stress and TNFα are critically involved in the initiation and progression of non-
alcoholic fatty liver disease (NAFLD). In this study, we investigated the effects of …

The suppressor of cytokine signaling 2 (SOCS2) acts as substrate recognition subunit of a
Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as …

Morphogenesis requires the proper migration and positioning of different cell types in the
embryo. Much more is known about how cells start and guide their migrations than about …

SOCS3 is an inducible negative feedback inhibitor of cytokine signaling. Conditional
deletion of SOCS3 in mice using the Cre-lox system has now been applied to a range of cell …