Deregulated cytokine signaling is a characteristic feature of acute myeloid leukemia (AML),
and expression signatures of cytokines and chemokines have been identified as a …

The suppressor of cytokine signaling (SOCS) plays a negative role in the cytokine signaling
pathway, preventing excessive signaling from interfering with the metabolic homeostasis of …

The suppressor of cytokine signaling (SOCS) family members play crucial roles in regulating
immune signal pathways by acting as inhibitors of cytokine receptor signaling. In this study …

The signal transducer and activator of transcription (STAT) proteins are a family of latent
cytoplasmic transcription factors, which form dimers when activated by cytokine receptors …

Altered expression of suppressor of cytokine signaling (SOCS) is found in various tumors.
However, regulation of SOCS2 by upstream molecules has yet to be clearly elucidated …

We have previously shown that phospholipase D (PLD) downregulation accelerates cellular
senescence, which is widely believed to play an important role in aging, by stimulating …

Hepatocellular carcinoma (HCC) is one of the most common primary liver malignancies and
is the third leading cause of tumor-related mortality worldwide. Despite advances in HCC …

Abstract Growth hormone (GH)/STAT5 signaling is desensitized in liver of adult transgenic
mice overexpressing GH; however, these animals present greater body size. To assess if the …

SOCS2, a member of suppressor of cytokine signaling (SOCS) family, is a negative regulator
of the signal pathway Janus kinase/signal transducers and activators of transcription …

Suppressor of cytokine signaling (SOCS) proteins are primarily feedback inhibitors of
cytokine signaling. The two conserved domains of SOCS proteins have distinct functions …