Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis
Understanding the molecular mechanisms controlling normal hematopoietic differentiation is
critical to develop new treatments for blood diseases and to manipulate stem cells. Despite …
critical to develop new treatments for blood diseases and to manipulate stem cells. Despite …
Antheraea pernyi Suppressor of Cytokine Signaling 2 Negatively Modulates the JAK/STAT Pathway to Attenuate Microbial Infection
S Kausar, I Gul, R Liu, XX Ke, Z Dong… - International Journal of …, 2022 - mdpi.com
The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway has
been shown to govern various physiological processes, including immune responses …
been shown to govern various physiological processes, including immune responses …
Molecular identification of suppressor of cytokine signaling 2 (SOCS2) and its response to BmNPV in Bombyx mori (Lepidoptera: Bombycidae)
X Zhang, Q Wang, M Cui, C Zhang, Y Wu… - Journal of Asia-Pacific …, 2024 - Elsevier
The suppressor of cytokine signaling 2 (SOCS2), an essential member of the SOCS family,
is a classic negative regulator of the JAK-STAT-IFN signaling pathway. Current research …
is a classic negative regulator of the JAK-STAT-IFN signaling pathway. Current research …
Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2
H Kiu, CJ Greenhalgh, A Thaus, DJ Hilton… - Growth …, 2009 - Taylor & Francis
Suppressor of cytokine signalling (SOCS) 3 is an essential regulator of cytokine signalling,
and in turn its expression is tightly regulated. Data from overexpression studies in cell lines …
and in turn its expression is tightly regulated. Data from overexpression studies in cell lines …
SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease
MRG Santos, IM Chaves, CM Queiroz-Junior… - Inflammation …, 2023 - Springer
Introduction The role of suppressor of cytokine signaling 2 (SOCS2) in Aggregatibacter
actinomycetemcomitans (Aa)-induced alveolar bone loss is unknown; thus, it was …
actinomycetemcomitans (Aa)-induced alveolar bone loss is unknown; thus, it was …
Feeding a high dosage of zinc oxide affects suppressor of cytokine gene expression in Salmonella Typhimurium infected piglets
JN Schulte, GA Brockmann… - Veterinary Immunology and …, 2016 - Elsevier
Suppressor of cytokine signaling (SOCS) proteins play an important role in the regulation of
the immune response by inhibiting cytokines. Here we investigated the effects of zinc oxide …
the immune response by inhibiting cytokines. Here we investigated the effects of zinc oxide …
Molecular characterization, expression pattern and evolution of nine suppressors of cytokine signaling (SOCS) gene in the swamp eel (Monopterus albus)
B Tian, D Tang, J Wu, M Liang, D Hao - Fish & shellfish immunology, 2020 - Elsevier
Suppressors of cytokine signaling (SOCS) family members have negative effects on cytokine
signaling pathways involved in immunity, growth and development. Owing to their typical …
signaling pathways involved in immunity, growth and development. Owing to their typical …
[PDF][PDF] Negative regulation of leptin receptor signalling
D Lavens, J Piessevaux, J Tavernier - European cytokine network, 2006 - Citeseer
Leptin was discovered as an adipostat, regulating body weight by balancing food intake and
energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial …
energy expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial …
SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function
N Hansen, H Ågerstam, M Wahlestedt, N Landberg… - Leukemia, 2013 - nature.com
Suppressor of cytokine signaling 2 (SOCS2) is known as a feedback inhibitor of cytokine
signaling and is highly expressed in primary bone marrow (BM) cells from patients with …
signaling and is highly expressed in primary bone marrow (BM) cells from patients with …
Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps
F Bogazzi, F Ultimieri, F Raggi, D Russo… - Clinical …, 2009 - Wiley Online Library
Background Acromegalic patients have increased prevalence of colonic polyps.
Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) …
Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) …