Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial
compartment, despite the presence of non-neoplastic stromal components that substantially …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is
characterized by high recurrence and heterogeneity, yet its mechanism is not well …

Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …

Background & Aims Angiocrine signaling by liver sinusoidal endothelial cells (LSECs)
regulates hepatic functions such as growth, metabolic maturation, and regeneration …

Liver sinusoidal endothelial cells (LSEC) form a unique barrier between the liver sinusoids
and the underlying parenchyma, and thus play a crucial role in maintaining metabolic and …

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases
worldwide. It is strongly associated with obesity, type 2 diabetes (T2DM), and other …

Background Dysfunction of liver sinusoidal endothelial cells (LSECs) is permissive for the
progression of liver fibrosis and cirrhosis and responsible for its clinical complications. Here …

Single-cell transcriptomics (scRNA-seq) has revolutionized the understanding of the spatial
architecture of tissue structure and function. Advancing the" transcript-centric" view of scRNA …