[HTML][HTML] Current molecular-targeted therapies in NSCLC and their mechanism of resistance

Z Schrank, G Chhabra, L Lin, T Iderzorig, C Osude… - Cancers, 2018 - mdpi.com
Lung cancer is treated with many conventional therapies, such as surgery, radiation, and
chemotherapy. However, these therapies have multiple undesirable side effects. To bypass …

[HTML][HTML] MET amplification as a resistance driver to TKI therapies in lung cancer: clinical challenges and opportunities

K Qin, L Hong, J Zhang, X Le - Cancers, 2023 - mdpi.com
Simple Summary Secondary amplifications/copy number changes of the gene MET (MET
protocol oncogene) play a significant role in the development of resistance to targeted drugs …

[HTML][HTML] Mediating EGFR-TKI resistance by VEGF/VEGFR autocrine pathway in non-small cell lung cancer

C Osude, L Lin, M Patel, A Eckburg, J Berei, A Kuckovic… - Cells, 2022 - mdpi.com
Simple Summary Non-small cell lung cancer (NSCLC) patients acquire resistance to
tyrosine kinase inhibitors (TKIs) via EGFR mutations or overexpression of vascular …

[HTML][HTML] Combination strategies using EGFR-TKi in NSCLC therapy: learning from the gap between pre-clinical results and clinical outcomes

Z Yang, KY Tam - International journal of biological sciences, 2018 - ncbi.nlm.nih.gov
Although epidermal growth factor receptor (EGFR) inhibitors have been used to treat non-
small cell lung cancer (NSCLC) for decades with great success in patients with EGFR …

[HTML][HTML] Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular …

D Xie, X Wu, L Lan, F Shangguan, X Lin, F Chen… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Mitochondrial transcription factor A (TFAM) is essential for the replication, transcription and
maintenance of mitochondrial DNA (mtDNA). The role of TFAM in non-small cell lung cancer …

[HTML][HTML] Clinical utility of liquid biopsy-based companion diagnostics in the non-small-cell lung cancer treatment

Y Sato - Exploration of Targeted Anti-Tumor Therapy, 2022 - ncbi.nlm.nih.gov
Recently, technological advances in the detection and biological characterization of
circulating tumor DNA (ctDNA) have enabled the implementation of liquid biopsy testing into …

[HTML][HTML] Cancer: we should not forget the past

A Di Lonardo, S Nasi, S Pulciani - Journal of cancer, 2015 - ncbi.nlm.nih.gov
Cancer has been in existence longer than human beings, and man has been facing the
illness ever since he made his appearance on Earth. Amazingly, the first human cancer …

[HTML][HTML] Drug eluting stents for malignant airway obstruction: a critical review of the literature

W Hohenforst-Schmidt, P Zarogoulidis, G Pitsiou… - Journal of …, 2016 - ncbi.nlm.nih.gov
Lung cancer being the most prevalent malignancy in men and the 3 rd most frequent in
women is still associated with dismal prognosis due to advanced disease at the time of …

Polymer-based platforms by electric field-assisted techniques for tissue engineering and cancer therapy

V Guarino, V Cirillo, R Altobelli… - Expert review of medical …, 2015 - Taylor & Francis
A large variety of processes and tools has been investigated to acquire better knowledge on
the natural evolution of healthy or pathological tissues in 3D scaffolds to discover new …

[HTML][HTML] Early diagnostic and prognostic value of serum exosomal miR-1246 in non-small cell lung cancer

D Huang, D Qu - International Journal of Clinical and Experimental …, 2020 - ncbi.nlm.nih.gov
Lung cancer is one of the most common malignant tumors. A growing body of evidence has
demonstrated that circulating microRNAs (miRNAs) have great potential for the diagnosis …