Mitochondrial uncoupling can be defined as a dissociation between mitochondrial
membrane potential generation and its use for mitochondria-dependent ATP synthesis …

Complex multicellular organisms require a coordinated response from multiple tissues to
maintain whole-body homeostasis in the face of energetic stressors such as fasting, cold …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

Exercise training results in beneficial adaptations to numerous tissues and offers protection
against metabolic disorders including obesity and type 2 diabetes. Multiple studies have …

The ability to generate thermogenic fat could be a targeted therapy to thwart obesity and
improve metabolic health. Brown and beige adipocytes are two types of thermogenic fat …

Exercise training is a powerful means to combat metabolic diseases. Mice are extensively
used to investigate the benefits of exercise, but mild cold stress induced by ambient housing …

Obesity exacerbates aging-induced adipose tissue dysfunction. This study aimed to
investigate the effects of long-term exercise on inguinal white adipose tissue (iWAT) and …

Background Temperature stress was reported to impact the gut-brain axis including
intestinal microbiome and neuroinflammation, but the molecular markers involved remain …

The relationship between liver interleukin-6 (IL-6) resistance following high-fat diet (HFD)-
induced obesity and glucose intolerance is unclear. The purpose of this study was to assess …

Various endocrine factors contribute to cold‐induced white adipose tissue (WAT) browning,
but glucagon has largely been ignored. The purpose of the current investigation was to …