Microfluidic technologies' ability to miniaturize assays and increase experimental throughput
have generated significant interest in the drug discovery and development domain. These …

Nonlinear pharmacokinetics and pharmacodynamics may result from several capacity-
limited processes and often represent complicating factors in characterizing the …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

This leading textbook in the field examines the mechanisms underlying toxicity, particularly
the events at the molecular level and the factors that determine and affect toxicity. The new …

Background and objective The activity of cytochrome P450 (CYP) enzymes, which
determine the rate of elimination of lipid‐soluble drugs, demonstrates considerable …

Systematic evidence regarding herb‐drug interactions is lacking. This study investigated
herb‐drug interactions with warfarin. S‐warfarin concentration and response (prothrombin …

It is widely recognized that pharmacokinetic optimization needs to be addressed early in
drug discovery to reduce the high failure rate in bringing drugs to market. Poor absorption …

The history of drug discovery spans approximately 200,000 years. For much of this time, the
identification of therapeutic agents was empirical, with the shift to a more hypothesis-driven …

Pharmacokinetics is a branch of pharmacology that examines how drug concentrations
change with respect to time as a function of absorption, distribution, metabolism and …

The drug discovery and development pipeline have more and more relied on in vitro testing
and in silico predictions to reduce investments and optimize lead compounds. A …