Chronic obstructive pulmonary disease in never-smokers: risk factors, pathogenesis, and implications for prevention and treatment

IA Yang, CR Jenkins, SS Salvi - The Lancet Respiratory Medicine, 2022 - thelancet.com
Chronic obstructive pulmonary disease (COPD) was traditionally thought to be caused by
tobacco smoking. However, recognition of the importance of non-smoking-related risk …

[HTML][HTML] The pathology of small airways disease in COPD: historical aspects and future directions

A Higham, AM Quinn, JED Cançado, D Singh - Respiratory research, 2019 - Springer
Small airways disease (SAD) is a cardinal feature of chronic obstructive pulmonary disease
(COPD) first recognized in the nineteenth century. The diverse histopathological features …

[HTML][HTML] Definition and nomenclature of chronic obstructive pulmonary disease: time for its revision

B Celli, L Fabbri, G Criner, FJ Martinez… - American journal of …, 2022 - atsjournals.org
Attempts to define concepts and things date back to the time of Aristotle, around 2,400 years
ago, when he proposed that a definition should state the essential nature or being of …

[HTML][HTML] Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary

A Agustí, BR Celli, GJ Criner, D Halpin… - American journal of …, 2023 - atsjournals.org
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) has published the
complete 2023 GOLD report, which can be freely downloaded from its web page (www …

[HTML][HTML] From GOLD 0 to pre-COPD

MLK Han, A Agusti, BR Celli, GJ Criner… - American journal of …, 2021 - atsjournals.org
The diagnosis of chronic obstructive pulmonary disease (COPD) currently requires the
demonstration of poorly reversible airflow limitation, defined as a post-bronchodilator …

Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

G Radicioni, A Ceppe, AA Ford, NE Alexis… - The Lancet …, 2021 - thelancet.com
Background We previously described the contributions of increased total airway mucin
concentrations to the pathogenesis and diagnosis of the chronic bronchitic component of …

Advances in chronic obstructive pulmonary disease

MC Ferrera, WW Labaki, MLK Han - Annual review of medicine, 2021 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder with
significant morbidity and mortality. Despite its prevalence, COPD is underdiagnosed, and …

Lung microbiota and metabolites collectively associate with clinical outcomes in milder stage chronic obstructive pulmonary disease

SS Madapoosi, C Cruickshank-Quinn… - American journal of …, 2022 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is variable in its development.
Lung microbiota and metabolites collectively may impact COPD pathophysiology, but …

Chronic obstructive pulmonary disease biomarkers and their interpretation

RA Stockley, DMG Halpin, BR Celli… - American journal of …, 2019 - atsjournals.org
The pathology and impact of chronic obstructive pulmonary disease (COPD) results from an
abnormal inflammatory process resulting in tissue damage with ineffective repair in …

[HTML][HTML] Regenerative metaplastic clones in COPD lung drive inflammation and fibrosis

W Rao, S Wang, M Duleba, S Niroula, K Goller, J Xie… - Cell, 2020 - cell.com
Chronic obstructive pulmonary disease (COPD) is a progressive condition of chronic
bronchitis, small airway obstruction, and emphysema that represents a leading cause of …