PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy

F Abedi-Gaballu, G Dehghan, M Ghaffari, R Yekta… - Applied materials …, 2018 - Elsevier
Drug delivery systems for cancer chemotherapy are employed to improve the effectiveness
and decrease the side-effects of highly toxic drugs. Most chemotherapy agents have …

Mechanisms of drug release in nanotherapeutic delivery systems

PT Wong, SK Choi - Chemical reviews, 2015 - ACS Publications
Targeted drug delivery refers to an established therapeutic strategy that develops platforms
and nanoscale devices for selective delivery of small drug molecules and therapeutic genes …

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

Y Cheng, L Zhao, Y Li, T Xu - Chemical Society Reviews, 2011 - pubs.rsc.org
In the past decade, nanomedicine with its promise of improved therapy and diagnostics has
revolutionized conventional health care and medical technology. Dendrimers and dendrimer …

Formation of gold nanostar-coated hollow mesoporous silica for tumor multimodality imaging and photothermal therapy

X Li, L Xing, K Zheng, P Wei, L Du… - ACS applied materials …, 2017 - ACS Publications
Development of multifunctional nanoplatforms for tumor multimode imaging and therapy is of
great necessity. Herein, we report a new type of Au nanostar (NS)-coated, perfluorohexane …

Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles

J Zhu, L Zheng, S Wen, Y Tang, M Shen, G Zhang… - Biomaterials, 2014 - Elsevier
Abstract Development of multifunctional theranostic nanoplatforms for targeted cancer
imaging and therapy still remains a great challenge. Herein, we report the use of …

Theoretical and computational studies of dendrimers as delivery vectors

Y Ma - Chemical Society Reviews, 2013 - pubs.rsc.org
It is a great challenge for nanomedicine to develop novel dendrimers with maximum
therapeutic potential and minimum side-effects for drug and gene delivery. As delivery …

Dendrimer-based nanodevices for targeted drug delivery applications

J Zhu, X Shi - Journal of Materials Chemistry B, 2013 - pubs.rsc.org
This review reports some recent advances on the use of dendrimers as a versatile platform
for targeted drug delivery applications. The unique 3-dimensional architectures and …

Dendrimer-based molecular imaging contrast agents

Z Qiao, X Shi - Progress in polymer science, 2015 - Elsevier
This review reports recent advances on the use of dendrimer nanotechnology to build up
various contrast agents for different single-mode or dual-mode molecular imaging …

Multifunctional lactobionic acid-modified dendrimers for targeted drug delivery to liver cancer cells: investigating the role played by PEG spacer

F Fu, Y Wu, J Zhu, S Wen, M Shen… - ACS applied materials & …, 2014 - ACS Publications
We report the development of a lactobionic acid (LA)-modified multifunctional dendrimer-
based carrier system for targeted therapy of liver cancer cells overexpressing …

Doxorubicin-conjugated PAMAM dendrimers for pH-responsive drug release and folic acid-targeted cancer therapy

M Zhang, J Zhu, Y Zheng, R Guo, S Wang, S Mignani… - Pharmaceutics, 2018 - mdpi.com
We present here the development of multifunctional doxorubicin (DOX)-conjugated poly
(amidoamine)(PAMAM) dendrimers as a unique platform for pH-responsive drug release …