p21 in cancer research
B Shamloo, S Usluer - Cancers, 2019 - mdpi.com
p21 functions as a cell cycle inhibitor and anti-proliferative effector in normal cells, and is
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …
dysregulated in some cancers. Earlier observations on p21 knockout models emphasized …
RNA interference: biology, mechanism, and applications
N Agrawal, PVN Dasaradhi, A Mohmmed… - Microbiology and …, 2003 - Am Soc Microbiol
Double-stranded RNA-mediated interference (RNAi) is a simple and rapid method of
silencing gene expression in a range of organisms. The silencing of a gene is a …
silencing gene expression in a range of organisms. The silencing of a gene is a …
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
SM Elbashir, J Harborth, W Lendeckel, A Yalcin… - nature, 2001 - nature.com
RNA interference (RNAi) is the process of sequence-specific, post-transcriptional gene
silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is …
silencing in animals and plants, initiated by double-stranded RNA (dsRNA) that is …
RNA interference is mediated by 21-and 22-nucleotide RNAs
SM Elbashir, W Lendeckel, T Tuschl - Genes & development, 2001 - genesdev.cshlp.org
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
silencing in many organisms by a process known as RNA interference (RNAi). Using a …
[HTML][HTML] RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
Double-stranded RNA (dsRNA) directs the sequence-specific degradation of mRNA through
a process known as RNA interference (RNAi). Using a recently developed Drosophila in …
a process known as RNA interference (RNAi). Using a recently developed Drosophila in …
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans
L Timmons, DL Court, A Fire - Gene, 2001 - Elsevier
Genetic interference mediated by double-stranded RNA (RNAi) has been a valuable tool in
the analysis of gene function in Caenorhabditis elegans. Here we report an efficient …
the analysis of gene function in Caenorhabditis elegans. Here we report an efficient …
A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic …
KS Makarova, NV Grishin, SA Shabalina, YI Wolf… - Biology direct, 2006 - Springer
Background All archaeal and many bacterial genomes contain Clustered Regularly
Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR …
Interspaced Short Palindrome Repeats (CRISPR) and variable arrays of the CRISPR …
[HTML][HTML] Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
SM Elbashir, J Martinez, A Patkaniowska… - The EMBO …, 2001 - embopress.org
Duplexes of 21–23 nucleotide (nt) RNAs are the sequence-specific mediators of RNA
interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short …
interference (RNAi) and post-transcriptional gene silencing (PTGS). Synthetic, short …
[HTML][HTML] Non-coding RNAs: the architects of eukaryotic complexity
JS Mattick - EMBO reports, 2001 - embopress.org
Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene
regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA …
regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA …
[HTML][HTML] The rde-1 gene, RNA interference, and transposon silencing in C. elegans
Double-stranded (ds) RNA can induce sequence-specific inhibition of gene function in
several organisms. However, both the mechanism and the physiological role of the …
several organisms. However, both the mechanism and the physiological role of the …