Heat shock proteins; an overview
Heat shock proteins (Hsps) protect protein substrates against conformational damage to
promote the function of the proteins, prevent aggregation and prevent formation of toxic …
promote the function of the proteins, prevent aggregation and prevent formation of toxic …
Copper-mediated β-amyloid toxicity and its chelation therapy in Alzheimer's disease
The link between bio-metals, Alzheimer's disease (AD), and its associated protein, amyloid-
β (Aβ), is very complex and one of the most studied aspects currently. Alzheimer's disease, a …
β (Aβ), is very complex and one of the most studied aspects currently. Alzheimer's disease, a …
Prediction of protein solubility based on sequence physicochemical patterns and distributed representation information with DeepSoluE
Background Protein solubility is a precondition for efficient heterologous protein expression
at the basis of most industrial applications and for functional interpretation in basic research …
at the basis of most industrial applications and for functional interpretation in basic research …
SOLpro: accurate sequence-based prediction of protein solubility
Motivation: Protein insolubility is a major obstacle for many experimental studies. A
sequence-based prediction method able to accurately predict the propensity of a protein to …
sequence-based prediction method able to accurately predict the propensity of a protein to …
The conformational quality of insoluble recombinant proteins is enhanced at low growth temperatures
A Vera, N González‐Montalbán, A Arís… - Biotechnology and …, 2007 - Wiley Online Library
Protein aggregation is a major bottleneck during the bacterial production of recombinant
proteins. In general, the induction of gene expression at sub‐optimal growth temperatures …
proteins. In general, the induction of gene expression at sub‐optimal growth temperatures …
Bacterial inclusion bodies contain amyloid-like structure
Protein aggregation is a process in which identical proteins self-associate into imperfectly
ordered macroscopic entities. Such aggregates are generally classified as amorphous …
ordered macroscopic entities. Such aggregates are generally classified as amorphous …
[HTML][HTML] Effect of temperature on protein quality in bacterial inclusion bodies
NS de Groot, S Ventura - FEBS letters, 2006 - Elsevier
Increasing evidence indicates that protein aggregation in bacteria does not necessarily
imply loss of biological activity. Here, we have investigated the effect of growth-temperature …
imply loss of biological activity. Here, we have investigated the effect of growth-temperature …
Kinetics of Inclusion Body Formation and Its Correlation with the Characteristics of Protein Aggregates in Escherichia coli
The objective of the research was to understand the structural determinants governing
protein aggregation into inclusion bodies during expression of recombinant proteins in …
protein aggregation into inclusion bodies during expression of recombinant proteins in …
[HTML][HTML] Inclusion bodies: specificity in their aggregation process and amyloid-like structure
M Morell, R Bravo, A Espargaró, X Sisquella… - … et Biophysica Acta (BBA …, 2008 - Elsevier
The accumulation of aggregated protein in the cell is associated with the pathology of many
diseases and constitutes a major concern in protein production. Intracellular aggregates …
diseases and constitutes a major concern in protein production. Intracellular aggregates …
Autophagy modulation in aggresome formation: Emerging implications and treatments of Alzheimer's disease
Alzheimer's disease (AD) is one of the most prevailing neurodegenerative diseases in the
world, which is characterized by memory dysfunction and the formation of tau and amyloid β …
world, which is characterized by memory dysfunction and the formation of tau and amyloid β …