In mammals, the production of mature oocytes necessitates rigorous regulation of the
discontinuous meiotic cell-cycle progression at both the transcriptional and post …

It is a well-known fact that the reproductive organs in women, especially oocytes, are
exposed to numerous regulatory pathways and environmental stimuli. The maternal age is …

The understanding of the mechanisms that regulate gene expression to establish
differentiation programs and determine cell lineages, is one of the major challenges in …

DNA repair defects underlie many cancer syndromes. We tested whether de novo germline
mutations (DNMs) are increased in families with germline defects in polymerase …

Background The transcriptional changes around zygotic genome activation (ZGA) in
preimplantation embryos are critical for studying mechanisms of embryonic developmental …

Maternal metabolic disorders may cause lipotoxic effects on the developing oocyte.
Understanding the timing at which this might disrupt embryo epigenetic programming and …

The development of the ovarian antral follicle is a complex, highly regulated process.
Oocytes orchestrate and coordinate the development of mammalian ovarian follicles, and …

The oocyte transcriptome follows a tightly controlled dynamic that leads the oocyte to grow
and mature. This succession of distinct transcriptional states determines embryonic …

Introduction Acquisition of germinal vesicle (GV) stage oocytes for fertility preservation (FP)
offers several benefits over in vivo matured oocyte cryopreservation following ovarian …

EXOSC10 is a catalytic subunit of the nuclear RNA exosome, and possesses a 3'-
5'exoribonuclease activity. The enzyme processes and degrades different classes of RNAs …