Microglia of the aged brain: primed to be activated and resistant to regulation

DM Norden, JP Godbout - Neuropathology and applied …, 2013 - Wiley Online Library
Innate immunity within the central nervous system (CNS) is primarily provided by resident
microglia. Microglia are pivotal in immune surveillance and also facilitate the co‐ordinated …

The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells

SV Maurer, CL Williams - Frontiers in immunology, 2017 - frontiersin.org
Degeneration of central cholinergic neurons impairs memory, and enhancement of
cholinergic synapses improves cognitive processes. Cholinergic signaling is also anti …

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

DM Norden, MM Muccigrosso, JP Godbout - Neuropharmacology, 2015 - Elsevier
Glia of the central nervous system (CNS) help to maintain homeostasis in the brain and
support efficient neuronal function. Microglia are innate immune cells of the brain that …

[HTML][HTML] Phytochemicals and cognitive health: Are flavonoids doing the trick?

I Bakoyiannis, A Daskalopoulou, V Pergialiotis… - Biomedicine & …, 2019 - Elsevier
Flavonoids constitute a large group of polyphenolic compounds with numerous effects on
behaviour and cognition. These effects vary from learning and memory enhancement to an …

Immunomodulatory effects of flavonoids: possible induction of T CD4+ regulatory cells through suppression of mTOR pathway signaling activity

A Hosseinzade, O Sadeghi… - Frontiers in …, 2019 - frontiersin.org
The increasing rate of autoimmune disorders and cancer in recent years has been a
controversial issue in all aspects of prevention, diagnosis, prognosis and treatment. Among …

Protection against Alzheimer's disease by luteolin: Role of brain glucose regulation, anti‐inflammatory activity, and the gut microbiota‐liver‐brain axis

JW Daily, S Kang, S Park - Biofactors, 2021 - Wiley Online Library
Luteolin is a widely distributed flavone herbs and vegetables. It has anti‐oxidant and anti‐
inflammatory activities and improves glucose metabolism by potentiating insulin sensitivity …

Beneficial roles of honey polyphenols against some human degenerative diseases: A review

MS Hossen, MY Ali, MHA Jahurul… - Pharmacological …, 2017 - Elsevier
Honey contains many active constituents and antioxidants such as polyphenols.
Polyphenols are phytochemicals, a generic term for the several thousand plant-based …

Paving Luteolin Therapeutic Potentialities and Agro‐Food‐Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

Y Taheri, J Sharifi-Rad, G Antika… - Oxidative Medicine …, 2021 - Wiley Online Library
Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As
many other natural flavonoids, it is often found in combination with glycosides in many fruits …

Molecular mechanism underlying anti-inflammatory and anti-allergic activities of phytochemicals: an update

Y Bellik, L Boukraâ, HA Alzahrani, BA Bakhotmah… - Molecules, 2012 - mdpi.com
The resort worldwide to edible medicinal plants for medical care has increased significantly
during the last few years. Currently, there is a renewed interest in the search for new …

Neuroinflammation: modulation by flavonoids and mechanisms of action

JPE Spencer, K Vafeiadou, RJ Williams… - Molecular aspects of …, 2012 - Elsevier
Neuroinflammatory processes are known to contribute to the cascade of events culminating
in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's …