The action potential of the squid giant axon is formed by just two voltage-dependent
conductances in the cell membrane, yet mammalian central neurons typically express more …

Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode
reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the …

Neuroinflammation is one of the hallmarks of Parkinson's disease (PD) and may contribute
to midbrain dopamine (DA) neuron degeneration. Recent studies link chronic inflammation …

The mesocorticolimbic dopamine system is essential for cognitive and emotive brain
functions and is thus an important target in major brain diseases like schizophrenia, drug …

Small-conductance Ca2+-activated K+ channels (SK channels) are widely expressed
throughout the central nervous system. These channels are activated solely by increases in …

Orexins/hypocretins are involved in mechanisms of emotional arousal and short-term
regulation of feeding. The dense projection of orexin neurons from the lateral hypothalamus …

The notion that prion-like spreading of misfolded α-synuclein (α-SYN) causes Parkinson9s
disease (PD) has received a great deal of attention. Although attractive in its simplicity, the …

Potassium channels are particularly important in determining the shape and duration of the
action potential, controlling the membrane potential, modulating hormone secretion …

Abstract Ca2+-activated K+ (KCa) channels of small (SK) and intermediate (IK) conductance
are present in a wide range of excitable and non-excitable cells. On activation by low …

Analgesic therapies are still limited and sometimes poorly effective, therefore finding new
targets for the development of innovative drugs is urgently needed. In order to validate the …