Reproducibility evaluation of urinary peptide detection using CE-MS

E Mavrogeorgis, H Mischak, A Latosinska, J Siwy… - Molecules, 2021 - mdpi.com
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been
increasingly applied in clinical research especially in the context of chronic and age …

Collagen-derived peptides in CKD: a link to fibrosis

E Mavrogeorgis, H Mischak, A Latosinska, A Vlahou… - Toxins, 2021 - mdpi.com
Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …

Urinary peptidomic liquid biopsy for non-invasive differential diagnosis of chronic kidney disease

E Mavrogeorgis, T He, H Mischak… - Nephrology Dialysis …, 2024 - academic.oup.com
Background and hypothesis Specific urinary peptides hold information on disease
pathophysiology, which, in combination with artificial intelligence, could enable non-invasive …

Discovery of Fibrinogen γ-chain as a potential urinary biomarker for renal interstitial fibrosis in IgA nephropathy

J Guan, M Wang, M Zhao, W Ni, M Zhang - BMC nephrology, 2023 - Springer
Abstract Background IgA nephropathy (IgAN) is a major cause of chronic kidney disease
(CKD). Renal interstitial fibrosis is a hallmark of CKD progression. Non-invasive biomarkers …

Comparative proteomic analysis of children FSGS FFPE tissues

J Ni, S Tian, L Bai, Q Lv, J Liu, J Liu, Y Fang, Y Zhai… - BMC pediatrics, 2022 - Springer
Background In children, focal segmental glomerulosclerosis (FSGS) is the main cause of
steroid resistant nephrotic syndrome (SRNS). To identify specific candidates and the …

Minimal Change Disease: Pathogenetic Insights from Glomerular Proteomics

AA Bărar, IE Pralea, Y Maslyennikov… - International Journal of …, 2024 - mdpi.com
The mechanism underlying podocyte dysfunction in minimal change disease (MCD)
remains unknown. This study aimed to shed light on the potential pathophysiology of MCD …

Gestational Age-Related Urinary Peptidome Changes in Preterm and Term Born Infants

M Brasseler, H Mischak, JP Schanstra, JM Michel… - Neonatology, 2024 - karger.com
Introduction: Preterm infants are at risk for a variety of somatic and neurological disorders. In
recent years, biofluid proteomics has emerged as a potential diagnostic tool for biomarker …

Uniform Manifold Approximation and Projection-based Assessment of Chronic Kidney Disease Aetiologies based on Urinary Peptidomics

E Mavrogeorgis, T He, H Mischak, A Latosinska… - medRxiv, 2023 - medrxiv.org
Background The impact of artificial intelligence combined with advanced techniques is ever-
increasing in the biomedical field appearing promising, among others, in chronic kidney …

[PDF][PDF] Collagen-Derived Peptides in CKD: A Link to Fibrosis. Toxins 2022, 14, 10

E Mavrogeorgis, H Mischak, A Latosinska, A Vlahou… - 2021 - drive.google.com
Collagen is a major component of the extracellular matrix (ECM) and has an imminent role
in fibrosis, in, among others, chronic kidney disease (CKD). Collagen alpha-1 (I)(col1a1) is …