One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Simple Summary The survival rate for pediatric cancers has improved significantly over the
last decades. Conventional chemotherapies play a vital role in pediatric cancer treatment …

Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …

Ferroptosis is a newly identified form of regulated cell death that is driven by iron overload
and uncontrolled lipid peroxidation, but the role of ferroptosis in cardiac microvascular …

Osteoporosis, characterized by an imbalance in bone homeostasis, is a global health
concern. Bone defects are difficult to heal in patients with osteoporosis. Classical drug …

Calycosin (CAL) is the main active component present in Astragalus and reportedly
possesses diverse pharmacological properties. However, the cardioprotective effect and …

The use of natural compounds as an alternative to synthetic molecules has become a
significant subject of interest in recent decades. Stilbenoids are a group of phenolic …

Background Doxorubicin (DOX) is a potent anticancer chemotherapeutic agent whose
clinical application is substantially constrained by its cardiotoxicity. The pathophysiology of …

Reversing ventricular remodeling represents a promising treatment for the post-myocardial
infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an …

Objective Doxorubicin (DOX) is commonly used for chemotherapy; however, its clinical
value is extremely dampened because of the fatal cardiotoxicity. Leucine zipper protein 1 …