It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

The enzyme xanthine oxidoreductase (XOR) catalyses the last step of purine degradation in
the highest uricotelic primates as a rate-limiting enzyme in nucleic acid catabolism. Although …

Background Cardiovascular risk is increased in patients with gout. We compared
cardiovascular outcomes associated with febuxostat, a nonpurine xanthine oxidase inhibitor …

Germline mutations in cellular-energy associated genes have been shown to lead to various
monogenic disorders. Notably, mitochondrial disorders often impact skeletal muscle, brain …

Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

Xanthine oxidoreductase (XOR) is a ubiquitous complex cytosolic molybdoflavoprotein
which controls the rate limiting step of purine catabolism by converting xanthine to uric acid …

Reactive oxygen species (ROS) are generated by several different cellular sources, and
their accumulation within the myocardium is widely considered to cause harmful oxidative …

As previous studies have reported finding an association between hyperuricemia and the
development of cardiovascular and chronic kidney disease, hyperuricemia is thought to be …

The purine analog xanthine oxidase (XO) inhibitors (XOIs), allopurinol and oxypurinol, have
been reported to protect against heart failure secondary to myocardial infarction or rapid …

Cellular metabolism generates the cytotoxic superoxide free radical, O2·−, and a family of
enzymes called superoxide dismutases (SOD) protects us from O2·− by catalyzing its …