Mechanisms of left ventricular (LV) dysfunction in isolated mitral regurgitation (MR) are not
well understood. Vasodilator therapy in other forms of LV dysfunction reduces LV wall stress …

Objective To investigate the association between using febuxostat and cardiovascular
events. Methods Systematic search of randomized controlled trials was performed using …

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with
volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of …

The prevalence of heart failure (HF) is still increasing worldwide, with enormous human,
social, and economic costs, in spite of huge efforts in understanding pathogenetic …

Purine nucleoside phosphorylase (PNP) and xanthine oxidase (XO) are key enzymes
involved in the purine salvage pathway. PNP metabolizes purine bases to synthetize purine …

Background Febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase (XO), may
be used in the prevention and management of atrial fibrillation (AF). The purpose of this …

The nonpurine selective xanthine oxidase (XO) inhibitor febuxostat attenuates development
of left ventricular (LV) hypertrophy and dysfunction in mice when treatment is initiated within …

Febuxostat is a novel, nonpurine, selective inhibitor of xanthine oxidase (NP-SIXO), recently
approved in the European Union. Febuxostat shows high, long-term efficacy for the …

目的: 观察巴戟天寡糖对大鼠心肌缺血再灌注损伤的影响. 方法: 将96 只Wistar
大鼠随机均分为假手术组, 缺血再灌注模型组, 阳性药物地奥心血康对照组和巴戟天寡糖0.7, 1.4 …

The modification of cell proteins by metabolically and environmentally induced redox
reactions significantly expands the functional proteome. These posttranslational …