One of the most common forms of genetic deafness has been predominantly associated with
pathogenic variants in the GJB2 gene, encoding transmembrane protein connexin 26 …

Abstract Background Connexin 43 (Cx43), the predominant gap junction protein in hearts, is
modified by specific (de) phosphorylation events under physiological and pathological …

Simple Summary Congenital heart disease is associated with substantial mortality and
morbidity as well as socioeconomic burden, and increasing research underscores the …

Background The brain extracellular fluid (ECF), composed of secreted neurotransmitters,
metabolites, peptides, and proteins, may reflect brain processes. Analysis of brain ECF may …

Gut barrier dysfunction occurs commonly in patients with critical disorders, leading to the
translocation of luminal toxic substances and bacteria to the bloodstream. Connexin 43 …

Aims Pulmonary hypertension (PH) is characterised by an increase in pulmonary arterial
pressure, ultimately leading to right ventricular failure and death. We have previously shown …

Connexin43 (Cx43) hemichannels form a pathway for cellular communication between the
cell and its extracellular environment. Under pathological conditions, Cx43 hemichannels …

Connexins (Cxs) are transmembrane proteins involved in the formation of hemichannels
and gap junctions (GJs). GJs are involved in various physiological functions, including …

Gap junctions (GJ) provide metabolic cooperation between cells through the direct
exchange of cytoplasmic components. The authors analyzed the effect of short-term hypoxic …

Connexin proteins are the building blocks of gap junctions and connexin hemichannels.
Both provide a pathway for cellular communication. Gap junctions support intercellular …