Chemical strategies to engineer hydrogels for cell culture

J Lou, DJ Mooney - Nature Reviews Chemistry, 2022 - nature.com
Two-dimensional and three-dimensional cell culture systems are widely used for biological
studies, and are the basis of the organoid, tissue engineering and organ-on-chip research …

Synthetic alternatives to Matrigel

EA Aisenbrey, WL Murphy - Nature Reviews Materials, 2020 - nature.com
Matrigel, a basement-membrane matrix extracted from Engelbreth–Holm–Swarm mouse
sarcomas, has been used for more than four decades for a myriad of cell-culture …

Recent advances in hyaluronic acid hydrogels for biomedical applications

CB Highley, GD Prestwich, JA Burdick - Current opinion in biotechnology, 2016 - Elsevier
Highlights•New modifications to hyaluronic acid (HA) enable both covalent crosslinking and
supramolecular assembly.•Composite HA hydrogels permit controlled drug delivery and …

Activated ester containing polymers: opportunities and challenges for the design of functional macromolecules

A Das, P Theato - Chemical Reviews, 2016 - ACS Publications
Rapidly growing demand of functional polymers in various interdisciplinary areas of
research has accentuated the need for modern synthetic tools to develop advanced …

[HTML][HTML] Challenges and strategies for improving the regenerative effects of mesenchymal stromal cell-based therapies

S Baldari, G Di Rocco, M Piccoli, M Pozzobon… - International journal of …, 2017 - mdpi.com
Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Graphene: A versatile platform for nanotheranostics and tissue engineering

RG Bai, N Ninan, K Muthoosamy… - Progress in Materials …, 2018 - Elsevier
The sustained extensive research on graphene and its derivatives in the last decade
portrayed its significance in the field of material science and carved its own niche in …

Tissue engineering strategies for promoting vascularized bone regeneration

S Almubarak, H Nethercott, M Freeberg, C Beaudon… - Bone, 2016 - Elsevier
This review focuses on current tissue engineering strategies for promoting vascularized
bone regeneration. We review the role of angiogenic growth factors in promoting …

Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering

G Yang, H Lin, BB Rothrauff, S Yu, RS Tuan - Acta biomaterialia, 2016 - Elsevier
Regeneration of injured tendon and ligament (T&L) remains a clinical challenge due to their
poor intrinsic healing capacity. Tissue engineering provides a promising alternative …

Heparin-based and heparin-inspired hydrogels: size-effect, gelation and biomedical applications

C He, H Ji, Y Qian, Q Wang, X Liu, W Zhao… - Journal of Materials …, 2019 - pubs.rsc.org
Heparin is the highest negatively charged biomolecule, which is a polysaccharide belonging
to the glycosaminoglycan family, and its role as a regulator of various proteins, cells and …

[HTML][HTML] Biomaterial-based endochondral bone regeneration: a shift from traditional tissue engineering paradigms to developmentally inspired strategies

EJ Sheehy, DJ Kelly, FJ O'Brien - Materials Today Bio, 2019 - Elsevier
There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever
increasing number of bone grafting procedures performed annually. Herein, we describe a …