Background: Sophoridine, the major active constituent of Sophora alopecuroides and its
roots, is a bioactive alkaloid with a wide range of pharmacological effects, including …

Background The therapeutic benefits of Niaoduqing granules (NDQG) in kidney diseases
has been comprehensively studied, but its adverse drug reactions remain unexplored …

Background Sophoridine (SR) has shown the potential to be an antiarrhythmic agent.
However, SR's electrophysiological properties and druggability research are relatively …

Background: The diagnosis and treatment of mixed vaginitis are more complicated than
single pathogenic infections, and there may be adverse reactions and several …

The discovery of alternative medicines with fewer adverse effects is urgently needed for
rheumatoid arthritis (RA). Sophoridine (SR), the naturally occurring quinolizidine alkaloid …

In this study, we used alkaloids from Sophora flavescens to inhibit the SASP, leading to
fibroblast-into-myofibroblast transition (FMT) to maintain intestinal mucosal homeostasis in …

Drug-induced liver injury (DILI) is a major challenge to the development and clinical
application of drugs, especially limits the global application of Chinese herbal medicines …

Pests cause substantial damage to human environments; therefore, studying insecticidal
mechanisms is crucial for improving pest control. However, the use of chemical pesticides …

Bone metabolism is characterized by an interplay between the deposition of bone matrix
and mineralization and the resorption process. Osteoporosis is a form of systemic metabolic …

Sophoridine, which is derived from the Leguminous plant Sophora alopecuroides L., has
certain pharmacological activity as a new anticancer drug. Herein, a series of novel N …